肝硬化顽固性腹水治疗中前列地尔对肾脏血流动力学的影响

Influence of Prostaglandin E1 on Renal Hemodynamics of Patients Suffered from Liver Cirrhosis with Refractory Ascites

目的观察前列地尔治疗肝硬化顽固性腹水对肾脏血流动力学的影响。方法选取肝硬化顽固性腹水患者平均血速度47例,随机分成治疗组和对照组,常规治疗基础上治疗组给予前列地尔20μg+5%葡萄糖注射液250 mL静脉滴注14 d,对照组给予多巴胺20 mg+5%葡萄糖注射液250 mL静脉滴注14 d。治疗前后均用彩色多普勒超声仪检测肾脏血流动力学的参数,观察变化。结果治疗组双侧肾动脉内经(D)、平均血流速度(V)以及血流阻力指数(RI)与治疗前比较,差异有显著统计学意义(P<0.01);治疗组D、V、RI与对照组比较,差异有显著统计学意义(P<0.01)。前列地尔治疗对肾脏血流动力学的影响显著优于对照组;对照组的复发率达到42.86%远远高于治疗组的15.38%,差异有统计学意义(P<0.05)。结论前列地尔在治疗肝硬化顽固性腹水中能够有效地改善肾脏血流动力,对肝硬化顽固性腹水的治疗有一定的疗效。

Objective To study the influence of prostaglandin E1 on renal hemodynamics of patients suffered from liver cirrhosis with refractory ascites. Methods PGE1 was given by intravenous drip 20]gg q.d for 14 days in 26 cases. The renal artery hemodynamics was studied before and after treatment by Color Doppler . Besides , Dopamine was given by intravenous drip in 21 cases as control . Results Treatment group D, V and RI compared with before treatment D, V and RI, （P〈0.01）,the results are statistically significant; Treatment group D, V and RI compared with Observation group D, V and RI, （P^0.01）,the results are statistically significant;Conclusion By improving renal hemodynamics, PGE1 has certain therapeutic effect to liver cirrhosis with refractory ascites.