一种新型消毒液ATQ-Zn的杀菌效果与毒理学评价研究

Study on germicidal efficacy and toxicology assessment of ATQ-Zn disinfectant

目的为研究ATQ-Zn消毒液杀菌效果和毒性。方法采用定量杀菌试验和动物试验进行杀菌效果和毒理学安全性评价。结果 ATQ-Zn消毒液对金黄色葡萄球菌、大肠杆菌、白色念球菌作用5 min,杀灭率均达到了99.99%;在54℃下放置14 d,37℃放置90 d杀菌效果无明显影响;该消毒液对大鼠急性经皮毒性试验属低毒;对家兔的一次完整皮肤刺激试验、眼刺激试验均属无刺激;豚鼠皮肤变态反应试验属轻度致敏物。结论新型消毒液ATQ-Zn具有杀菌效果好、稳定性强等优点,但大鼠经皮试验结果显示该消毒液属低毒类物质,豚鼠皮肤变态试验结果显示该消毒液属轻度致敏物。

Objective To study the germicidal efficacy and toxicity of a new ATQ-Zn disinfectant.Methods Quantitative germicidal test and animal toxicity test were used to carry out laboratory observation on the germicidal efficacy and toxicity of ATQ-Zn disinfectant.Results The average killing rates of Staphylococcus aureus,Escherichia coli,Candida albicans exposed to ATQ-Zn disinfectant for 5 min were all 99.99%;the germicidal efficacy was not significantly influenced when storied at 54℃ for 14 days and 37℃ for 90 days.The disinfectant solution was low toxic in acute dermal toxicity.No irritating effects were found on intact skin and eyes of test animals;it was mild allergens in guinea pig skin allergy test.Conclusion The new ATQ-Zn disinfectant has good germicidal efficacy and stability,but it was low toxic in acute dermal toxicity and mild allergens in guinea pig skin allergy test.