摘要
目的:研究颅内动脉瘤患者血清脂蛋白(a)及其它脂质相关成分水平变化,探讨Lp(a)在颅内动脉瘤发病过程中的作用。方法自2006年-2012年,我们分别收集并测定了颅内动脉瘤病人组(48例)和正常健康人对照组(50例)的血清Lp(a)及其它脂质相关成分的水平变化,并分析其与动脉瘤发病的相关性。结果颅内动脉瘤组脂蛋白(a)水平为(314.2±217.7 mg/L),明显高于正常对照组(133.5±99.7 mg/L),差异有统计学意义(P<0.05)。其它各项脂质(总胆固醇和甘油三酯),脂蛋白(HDL和LDL)和载脂蛋白(apoAl,apoB)水平在两组间均无明显差异。结论颅内动脉瘤患者的高Lp(a)水平与该疾病的发生发展有关,可能是导致动脉瘤形成的一种独立危险因子。
Objective To study the changes of serum lipoprotein（a） level and other serum lipids in intracranial aneurysm cases,and discuss the function of lipoprotein（a） in onset course of intracranial aneurysm.Methods From 2006 to 2012,serum Lp（a） level and other serum lipids in 48 patients with intracranial aneurysm and 50 healthy controls were measured to analyze the correlation between lipoprotein（a） and intracranial aneurysm.Results Serum Lp（a） level in the intracranial aneurysm（314.2 ± 217.7 mg / L） was significantly higher than that in control group（133.5 ±99.7 mg/L）（P 0.05）.There was no obvious differences in the levels of serum Total-triglyceride,Total-cholestero1,LDL-cholesterol,HDL-cholesterol,and apolipoprotein AI and B between the two groups.Conclusion The result indicate that higher level of lipoprotein（a） would associate with development of intracranial aneurysm,and it can be an independent risk factor for genesis of intracranial aneurysm.
出处
《中国卫生检验杂志》
北大核心
2013年第9期2120-2121,2124,共3页
Chinese Journal of Health Laboratory Technology
