122株粘质沙雷菌临床分布及耐药性变迁

Clinicaldistribution and antibiotic-resistance changes of 121 Serratia marcescens strains

目的了解粘质沙雷菌感染的分布及耐药性特征,为临床用药提供依据。方法收集本院2009年-2011年分离的122株粘质沙雷菌的药物敏感性试验结果,进行细菌的分布及耐药性的分析。结果分离的122株粘质沙雷菌,其中痰标本有87株（占73.1%）。粘质沙雷菌分离数不断增加。其耐药率〉95%的抗菌素有氨苄西林和头孢唑啉;耐药率为20%~50%的有头孢他啶、头孢噻肟、头孢吡肟、阿米卡星、庆大霉素、哌拉西林/他唑巴坦和复方新诺明;耐药率〈15%的有亚胺培南、美罗培南和左旋氧氟沙星。结论粘质沙雷菌耐药机制复杂,而且对抗生素具有多重耐药性,根据药敏试验合理应用抗菌素十分重要。

Objective To investigate the distribution characteristics and drug resistance of Serratia marcescens,and to provide basis for clinical medication.Methods The drug sensitivity test results of 122 Serratia marcescens isolates from Second Affiliated Hospital of Nanjing Medical University during 2009 and 2011 were collected to analyze the distribution and drug resistance.Results Serratia marcescens were mainly separated from sputum samples（87 / 122,73.1%）.The drug resistance rate more than 95% was found in ampicillin and cefazolin,between 20% and 50% was found in ceftazidime,cefotaxime,cefepime,amikacin,gentamicin,piperacillin-tazobactam and trimethoprim-sulfamethoxazole,less than 15% was found in imipenem,meropenem and levofloxacin.Conclusion Due to the complex resistant mechanism and multi-drug resistance to antibiotics of Serratia marcescens,it is very important to rationally use antibiotics according to susceptibility testing results.