血管紧张素原基因M235T多态性与云南彝族原发性高血压相关性研究

Relationship between angiotensinogen gene M235T polymorphism and essential hypertension in Yi people of Yunnan province

目的研究血管紧张素原(AGT)M235T多态性与云南彝族原发性高血压(EH)的相关性。方法采用PCRRFLP技术,检测云南省晋宁县231例彝族EH患者和173例彝族健康人的AGT基因M235T多态性,并对结果进行相关性分析。结果彝族EH组与对照组MM、MT、TT基因型频率分别为5.63%、32.47%、61.90%和7.51%、39.31%、53.18%,235T等位基因的频率分别为78.14%和72.83%。两组比较差异无统计学意义(P>0.05)。在彝族女性中,EH患者235T等位基因频率明显高于正常对照(P<0.05)。结论携带AGT基因235T等位基因是云南彝族女性EH发病的危险因素之一。

Objective To investigate the relationship between angiotensinogen （AGT） gene M235T polymorphism and essential hypertension（EH） in Yi people of Yunnan province. Methods In Jinning county of Yunnan province, 231 essential hypertension（EH） patients and 173 healthy people of Yi nationality were involved to detect the angiotensinogen （AGT） gene M235T polymorphism by PCR - RFLP. Then the possible association between the gene polymorphism and essential hypertension was analyzed. Results Frequencies for the MM, MT and TT genotypes were 5.63% , 32.47% and 61.90% in EH cases, and 7.51% , 39.31% and 53.18% in normal people, respectively. Derived allele frequencies for the 235T were 78.14% and 72.83% in EH cases and normal people respectively. There was no significant difference in M235T genotype distribution and allele frequency between normal people and EH cases （ P 〉 0.05 ）. But for female, frequency of 235T allele in EH cases was higher than that in normal people （ P 〈 0.05 ）. Conclusion The AGT 235T allele is a risk factor of EH in Yi females.