摘要
目的利用ACSL Math初步建立依地普仑在人体的血流限速生理模型,并进行不同给药剂量间的外推,评估药物的体内特征。方法运用ACSL专业软件对模型进行模拟,并将预测值和文献值比较。结果预测值和文献值的相关性良好,药代动力学参数基本一致。结论模型可以较好地预测依地普仑在人体的血药时间过程,但模型仍需进一步优化和修订。
Objective To initially build a flow-limited physiologically based pharmacokinetic model of escitalopram based on ACSL Math,and to extrapolate different doses for evaluating pharmacokinetic feature in vivo of the drug. Methods The model was simulated by professional software of ACSL and the predicted values were compared with the values from literatures. Results The correlation coefficient was good between the predicted values and the values from literatures, and the pharmacokinetie parameters were relatively similar. Conclusion The model can predict the concentration-time curve of Escitalopram in vi- vo, but the model still needs further optimization and revision.
出处
《现代医药卫生》
2013年第22期3396-3398,共3页
Journal of Modern Medicine & Health
关键词
西酞普兰
药代动力学
模型
理论
计算机模拟
Citalopram/pharmacokinetics
Models,theoretical
Computer simulation