CIDEC与胰岛素抵抗相关研究进展

Research advances on CIDEC in insulin resistance

我国肥胖儿童逐年增多,其中多数患儿合并有胰岛素抵抗。最近的研究发现细胞死亡诱导DNA断裂因子相似蛋白(CIDEC)参与胰岛素抵抗的发生发展。CIDEC通过调控脂质合成、聚集、分解从而保护胰岛素的靶器官免于脂毒性的作用。本文综述了CIDEC的结构和功能、CIDEC的表达调控机制以及CIDEC导致胰岛素抵抗的最新研究进展。作为新发现的脂滴相关蛋白,CIDEC有可能成为干预胰岛素抵抗的新靶点。

Childhood obesity has been rising dramatically in recent years and most patients are insulin resistant. Recent studies have indicated that cell death-inducing DFF45-1ike effector C （CIDEC） is responsible for the development of insulin resistance. CIDEC regulates adipogenesis, lipid storage and lipolysis, thus protecting insulin target tissues from lipotoxity. This paper reviews current findings on the structure and function of CIDEC, its transcriptional and post- translational regulations, and the underlying mechanism of CIDEC causing insulin resistance. As a novel lipid droplet protein, CIDEC may be a drug target for treatment of insulin resistance and relevant metabolic disorders.