载脂蛋白E2基因型与银屑病相关性的Meta分析

Meta-analysis: Correlation of Apolipoprotein E2 Genotype and Psoriasis

目的评价载脂蛋白E2基因型与银屑病的相关性。方法计算机检索1990-2012年Cochrane图书馆,MEDLINE,Springerlink,CNKI,万方医学网,CBM六个数据库有关载脂蛋白E和银屑病的相关文献,纳入研究载脂蛋白E与银屑病相关性非配对病例的对照研究。由3名评价者共同评价纳入研究的质量。采用RevMan5.2.5软件进行Meta分析。结果共纳入8个研究,包括银屑病患者993例,健康对照1 184例。银屑病组分离细胞DNA载脂蛋白E2基因型(e2/3+e2/2)明显高于健康对照组[OR合并=1.94,95%CI(1.48,2.54)],亚组分析结果显示欧洲亚组中银屑病组ApoE2基因型与健康对照组无明显差异性[OR亚洲=1.40,95%CI(0.96,2.04)];亚洲亚组中银屑病组ApoE2基因型高于健康对照组,差异有统计学意义[OR欧洲=2.76,95%CI(1.85,4.11)]。结论现有研究结果显示,银屑病与载脂蛋白E2基因型有关,ApoE2分子很可能是亚洲人银屑病发生发展的一个危险因素,但与欧洲人银屑病无统计学相关性。由于纳入研究存在选择性偏倚、报告性偏倚和测量性偏倚的可能性,影响了研究结果的可靠性,期待将来高质量的研究提供高质量的证据。

Objective To evaluate the correlation of apolipoprotein E2 genotype and psoriasis. Methods We searched the Cochrane library, MEDLINE, Springedink, CNKI, Wanfang medicine network, CBM database from 1990 to 2012 and adopt all of non-paired case-control studies that research the correlation of apolipoprotein E and psoriasis. Three researchers evaluate quality of included studies. Meta-analysis was performed by Rev- ManS. 2.5. Results Eight studies, including 993 cases of psoriasis patients and 1184 healthy volunteers were included. Apolipoprotein E2 genotype （ e2/3 ＋ e2/2） from separation of cellular DNA in psoriasis group was significantly higher than that in healthy Control group with~ OR = 1.94, 95% CI（ 1.48, 2.54） ~. Sub- group analysis revealed psoriatic ApoE2 genotype in the European subgroup and the healthy control group had no significant difference;psoriatic ApoE2 genotypes in the Asian subgroups were higher than that in the healthy control group, and the difference was statistically significant. Conclusion The existing research re- sults show that psoriasis is related to apolipoprotein E2 genotype. The ApoE2 molecule is likely to be a risk factor for the development of Asian psoriasis occurred, but no significant correlation with the Europeans pso- riasis. Due to the possibility of existence of selection bias, report and measurement bias, which affects the re- sults of reliability, researches of high quality are expected to provide evidence of high quality in future.