玫瑰痤疮发病因素调查及其紫外线最小红斑量测定

The Investigation of Rosacea Etiology and Assessement of its Minimal Erythema Dose in Response to UV

目的探讨玫瑰痤疮的发病因素及其紫外线最小红斑量检测。方法制定针对玫瑰痤疮发病因素的调查表，对收集的98例玫瑰痤疮患者调查表进行统计学分析；根据患者病情对其中42例进行紫外线最小红斑量检测。结果玫瑰痤疮的发病与多种因素相关，如辛辣刺激食物、精神因素、温度变化、外用药物、系统性疾病，29例（29．59％）患者有家族遗传史，其中检测的42例中34例（80．95％）患者紫外线最小红斑量值低于正常，中波紫外线最小红斑量值（ultravioletB—minimalethemadose，UVB—MED），为7．70和15．70mJ／em。，长波紫外线最小红斑量值（ultravioletA—minimalethemadose，UVA—MED）为（11．10±4．77）J／em‘（5．40～18．20J／cm2），而且与UVB—MED相比，UVA—MED及（UVA＋UVB）MED敏感的患者更易诱发病情加重，差异有统计学意义（P〈0．001；P〈0．01）。结论玫瑰痤疮的发病和许多因素有关，其中紫外线照射（特别是UVA）是很重要的诱因。

Objective To explore the incidence and risk factors of rosacea, and detect the minimal erythema dose （MED） to assess its sensitivity to Ultraviolet（UV） light. Metheds Ninety-eight patients with rosacea were recruited and questionnaire＆ Results According to our study, the pathogenesis of rosacea were related to many factors, such as hot and spicy food, psychological factors, temperature changes, topical medications, systemic disease, and 29（29.59% ） patients with family history. Among the 42 patients undergoing MED test, 54 patients（80.95% ） with rosacea were sensitive to UV：UVB-MED value were 7.70 and 15.70mJ/cm2, UVA-MED value was （ 11.10 ＋ 4.77 ） J/cmz （ range, 5.40 ~ 18.20mJ/cm~ ）. Moreover, heating environment exposure can aggravate the disease. The UVA sensitive and UVA-UVB double sensitive patients were with higher risks of rosacea than the UVA sensitive patients（ P 〈 0. 001 ;P 〈 0.01 ）. Conclusion There are many factors relate to rosacea, and UV irradiation especially UVA is one of the important factor.