皮肤型孢子丝菌病82例临床分析

Clinical Analysis of 82 Cases Cutaneous Sporotrichosis

目的分析皮肤型孢子丝菌病的临床和流行病学特征，探讨其有效的治疗及预防方法。方法对2011-2012年确诊的82例皮肤孢子丝菌病患者的病例资料进行回顾性分析，所有临床株进行形态学、ITS和钙调蛋白（CAL）基因测序为基础的分子鉴定。结果82例患者中，以60～70岁年龄段居多（28，05％），以淋巴管型（49例，59，76％）为主，1例治愈后复发。CAL基因序列比对证实为球形孢子丝菌。、结论该组皮肤型孢子丝菌病以淋巴管型为主，病原体以球形孢子丝茵为主，可能存在耐药菌株。中老年为易感人群。

Objective To analyze clinical and epidemiological characteristics of cutaneous sporotrichosis and explore the effective tragedy of treatment and preventions. Methods A retrospective analysis was conducted on 82 cases of sporotrichosis being diagnosed at dermatology hospital of Dalian from 2011 to 2012. All the clinical i- solates were identified by morphological features, growth temperature, assimilation test, and molecular iden- tification based on ITS and CAL genes sequencing. Results Among 82 cases,The most common age at onset was observed from 61 to 70 years old（28.05% ）. The most common clinical type was lymphocutaneous （59.76%）. One case recurring after cure. All the clinical strains were identified as sporothrix glohosa based on CAL sequencing. Conclusion Lymphocutaneous type sporotrichosis is the most common type in this group. S. globosa is the prevalent pathogen, there may be a resistant strain and the old-aged patients are sus- ceptible population.