艾滋病痴呆综合征的研究进展

Advances of Acquired Immune Deficiency Syndrome Dementia Complex

艾滋病痴呆综合征是人类免疫缺陷病毒感染后引起的最严重的中枢神经系统并发症,发病机制并不明确。临床表现有记忆力下降、抑郁、震颤、痴呆、大小便失禁等。目前国际通常采用艾滋病痴呆综合征临床分期进行疾病的严重程度评估。实验室检查并无特异性方法,临床诊断主要依靠排除性诊断。传统治疗艾滋病病毒感染主要有3种药物,近年来也有专门针对艾滋病痴呆综合征发病机制而研究的药物,取得了一定疗效。

Acquired immune deficiency syndrome （AIDS） dementia complex is a serious complication of AIDS patients, whose pathogenesis is not clear. Clinical manifestations are characterized by amnesia, depression, tremor, dementia, urinary and fecal incontinence. At present the clinical staging of the AIDS dementia complex is popular. There is no specific method in laboratory tests. Clinical diagnosis relies mainly on the exclusion. The traditional treatment of the AIDS is three kinds of drugs. In recent years there are some new drugs specifically on the pathogenesis of the AIDS dementia complex （ADC）.