CRF1受体调节及其信号通路与情感障碍的关系被引量：4

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摘要情感障碍表现为焦虑，抑郁，双向情感障碍等。严重影响了人们的日常生活和工作^[1]。情感障碍疾病的发生与应激有着密切的关系，一般人为过度应激后产生焦虑，抑郁等行为，而促肾上腺皮质激素释放因子（CRF）作为应激反应中的关键调节因子，在情感障碍疾病中起到重要作用^[2]。CRFl受体特异拈抗剂在鼠类和恒河猴模型上表现出抗焦虑、抗抑郁样行为的作用^[3]。小鼠脑室内注射CRF会使小鼠活动行为下降，产生焦虑，抑郁行为^[4]。本研究旨在对CRFl受体调节及其信号通路与情感障碍的机制做一综述。

作者郭斌胡晓梅钟静玫白洁

机构地区昆明理工大学医学院

出处《中国老年学杂志》 CAS CSCD 北大核心 2013年第23期6040-6042,共3页 Chinese Journal of Gerontology

基金国家自然科学基金项目(No.81160162) 云南省科技厅昆明医学院联合基金项目(No.2010CD197)

关键词情感障碍促肾上腺皮质激素释放因子信号通路 CRF1受体

分类号 Q51 [生物学—生物化学]

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