肿瘤相关巨噬细胞是胃癌重要的促进因素

Tumor Associated Macrophages as Major Promoters of Gastric Cancer

目的探讨巨噬细胞与胃癌发生、发展的关系。方法查阅国内、外相关文献并进行综述。结果胃癌微环境能够诱导巨噬细胞分化,而活化的巨噬细胞,尤其是一类肿瘤相关巨噬细胞又能通过分泌多种活性物质在局部促进肿瘤生长、侵袭和转移。结论巨噬细胞,尤其是肿瘤相关巨噬细胞在胃癌的发生、发展中起到了重要的作用,通过研究巨噬细胞与胃癌相互作用的关系,能够更加深入地了解胃癌的发病过程,并有助于找到新的治疗胃癌的方法。

Objective To explore the association ofmacrophages with carcinogenesis and development of gastric cancer. Method The related literatures at home and abroad were consulted and reviewed. Results The microenvironment of gastric cancer could induce the polarization of macrophages, and then the activated macrophages, especially the tumor associated macrophages, could in turn motivate the growth, invasion, and metastasis of tumor cells by secreting a series of active substances. Conclusions Macrophages, especially the tumor associated macrophages play an important role in the carcinogenesis and development of gastric cancer. Investigating the macrophages and their interaction with gastric cancer may lead to a profound understanding of carcinogenesis of gastric cancer as well as opening up a new prospect for treatment.