乙肝病毒感染与肝癌自发性破裂相关性研究的进展

Advanced Research of Association of HBV with Spontaneous Rupture of Hepatocellular Carcinoma

目的探讨乙肝病毒感染与肝癌自发性破裂出血的相关性及其机理。方法采用文献回顾的方法,对肝癌自发性破裂患者的有关血管病变资料加以整理并综述。结果肝癌自发性破裂患者的小动脉存在管壁受损,这与乙肝病毒感染引起的血管免疫性破坏密切相关。结论乙肝病毒感染引起的血管免疫性破坏可能是肝癌自发性破裂的重要原因。

Objective To study the relationship of hepatitis B virus （HBV） to spontaneous rupture of hepatocellular carcinoma （HCC-SR） and its mechanism. Method The related literatures about theory of HCC-SR were consulted and reviewed. Results The injury of small arteries was usually followed in patients with HCC-SR, which was related to vascular autoimmune injury caused by the HBV infection. The small arteries in which immune complex deposited were readily injured, as a result HCC-SR happened while vascular load increased. Conclusion The HBV infection resulted in vascular autoimmune injury maybe a important factor in the pathogenesis of HCC-SR.