摘要
目的观察肿瘤转移相关蛋白1(MTA1)与直肠癌淋巴结转移及预后的关系,探讨MTA1在直肠癌发生发展过程中的作用。方法应用免疫组化法和实时荧光定量PCR方法检测MTA1在45例人直肠癌和20例直肠息肉组织中的表达,并结合临床病理特征和生存资料进行相关分析。结果直肠癌组织中MTA1蛋白及mRNA的表达较直肠息肉组显著增加(P<0.05),MTA1表达与直肠癌淋巴结转移、Dukes临床分期密切相关(P<0.05)。MTA1阳性表达与生存率负相关(P<0.05)。结论 MTA1高表达促进直肠癌淋巴结转移,检测MTA1表达可成为直肠癌预后不良的重要指标。
Objective To investigate the relationship of the expression of metastasis-associated protein 1 （MTA1） with lymph node metastasis and prognosis in patients with colorectal carcinomas. Meetods The expressions of MTAI in 45 specimens of the colorectal cancer and 20 specimens of polyp of colorectal tissues were observed by immunohistochemistry and neal-time fluoreseent quantitative PCP. The correlation analysis was made between MTA1 and clinical parameters, and judged its role in colorectal prognosis by using Kaplan-Meier method. Results The expression levels of MTA 1 protein and mRNA were higher in tumor tissue than in the polyp tissue. The expression level of MTA1 was significantly correlated with Dukes stage and lymphatic metastasis. The positive rate of MTA1 expression was negatively correlated to the survival rate. Conclusion MTAI overexpression might be involved in lymphangiogenesis in colorectal cell carcinoma, MTA 1 might be a helpful marker for judging uroznosis in eolorectal cancer.
出处
《解剖科学进展》
CAS
2013年第6期548-550,共3页
Progress of Anatomical Sciences
基金
黑龙江省教育厅科研项目(No.12531745)
黑龙江省卫生厅科研项目(No.2012-282)
