基质金属蛋白酶9基因-1562位点C>T多态性与冠心病关系的Meta分析

Association of-1562C>T polymorphism of matrix metalloproteinase-9 gene and coronary artery disease:a meta-analysis

目的：评价基质金属蛋白酶-9基因-1562位点C〉T多态性与冠心病的关系。方法：通过PubMed，Elsevier，EMbase，CNKI等数据库搜索2012年11月30日以前发表的基质金属蛋白酶-9基因一1562位点C〉T多态性与冠心病关联性的病例对照研究文章，剔除不符合要求的文献，并根据各入选文献结果的同质性检验结果进行数据合并，计算总OR值，Meta分析采用Revman5．0及Stata11．0统计软件。结果：共有13篇病例对照研究纳入。Meta分析1Tr＋CT基因型比CC基因型OR=1．29（95％CI为1．13～1．47，P〈0．01）；T等位基因比c等位基因OR=1．27（95％CI为1．13-1．42，P〈0．01）；CT基因型比CC＋TT基因型OR=1．29（95％CI：1．13～1．48），P〈0．01）。结论：基质金属蛋白酶-9基因1562位点C〉T多态性与冠心病发病相关，基质金属蛋白酶-9基因1562位点T等位基因是冠心病易感性的标记基因。

AIM ： To evaluate the relationship of matrix metalloproteinase-9 gene -1562 C 〉 T polymorphisms with coronary artery disease （CAD）. METHODS： A literature search was conducted in PubMed, Elsevier, EMbase, and CNKI database to identify eligible case-control studies published before November 30, 2012 on the relationship between matrix metalloproteinase-9 gene -1562 C 〉 T polymorphism and CAD. The odds ratios of all the studies were combined, dependent on the results of heterogeneity tests among the individual studies. Review Manager （ v. 5.0） and Stata （ v. 11.0） were used for meta-analysis. RESULTS： A total of 13 case-control studies were identified. No publication bias was identified in the 13 reviewed studies. The summarized odds ratios of TT and CT genotype combination vs. CC genotype across all 13 studies was OR = 1.29 （95% , CI 1.13 - 1.47, P 〈0.01 ） , T genotype vs. C genotype was OR = 1.27 （95% , CI 1.13 - 1.42, P 〈0.01 ） , and CT genotype vs. CC and TY genotype combination was OR = 1.29 （95% , CI 1.13 - 1.48, P 〈 0. 01 ）. CONCLUSION ： C 〉 T polymorphism of the matrix metalloproteinase-9 gene -1562 is associated with CAD. T allele of matrix metalloproteinase-9 gene may be the susceptibility marker for CAD.