维生素D缺乏与高血压病患者血清NT-pro-BNP浓度的关系

Relationship between vitamin D deficiency and serum NT-pro-brain natriuretic peptide concentration in patients with hypertension

目的：研究高血压病患者中维生素D的缺乏与血清N末端脑钠尿肽原（NT-pro-BNP）浓度的关系。方法：选取2009年～2012年住院高血压病患者，根据血清25．羟维生素D[25（OH）D]浓度由高到低将入选患者分为4组：A组：对照组25（OH）D浓度i〉30ng／ml；B组：20ng／ml〈25（OH）D浓度〈30ng／ml；C组：10rig／ml〈25（OH）D浓度〈20ng／ml；D组：25（OH）D浓度≤10ng／ml，测定血清NT-pro-BNP浓度，并作受试者血清各指标与血清NT-pro-BNP浓度相关性的分析。结果：B组和c组血清NT-pro-BNP浓度较对照组没有显著性差异。D组血清NT-pro-BNP浓度较对照组明显升高，差异有统计学意义（P〈0．05），D组血清NT-pro-BNP浓度较c组升高，差异有统计学意义（P〈0．05），即随着血清25（OH）D浓度的降低其血清NT-pro-BNP浓度显著升高。受试者血糖、血钙、总胆固醇、三酰甘油、糖化血红蛋白（HbAlC）、同型半胱氨酸、肌酐、甲状旁腺素与血清NT-pro-BNP浓度没有相关性。结论：维生素D的缺乏明显增加高血压病患者发生心力衰竭的风险。

AIM： To study the relationship between vitamin D deficiency and serum NT-pro-brain natriuretic peptide in hypertensive patients. METHODS ： On the basis of the plasma levels of 25 （OH） D, hypertensive patients in our hospital from 2009 to 2012 were divided into four groups： control group with 25（0H） D density≥30 ng/ml, group B with 20 ng/ml 〈 25 （OH）D density 〈 30 ng/ml, group C with 10 ng/ml 〈 25 （OH） D density 〈 20 ng/ml and group D with 25 （OH） D density ~〈 10 ng/ml. Serum NT-pro-brain natriuretic peptide concentration was evaluated and the correlation between serum indexes and serum NT-pro-brain natriuretic peptide concentration was analyzed. RESULTS ： A total of 150 hypertensive patients aged 30 - 85 years were included in the study. No significant difference was found in the serum NT-pro-brain natriuretic peptide concentration between groups B and C and control group （95% C I ： - 38.63 - 195.92, P 〉 0. 05 ; 95% CI ： 84. 44 - 311.25, P 〉 0. 05 ）. Serum NT-pro-brain natli-uretic peptide concentration in group D was significantly higher than in control group （95 % CI ： 181.42 - 409.99, P 〈 0. 05 ） and was significantly higher than in group C. Serum NT-pro-brain natriuretic peptide concentration in each group markedly increased with the decrease of plasma levels of 25 （OH） D. No correlation was found between the serum NT-pro-brain natriuretic peptide concentration and serum indexes including blood sugar, blood calcium, total cholesterol, triglyceride, homocysteine, creatinine and parathormone. CONCLUSION： Vitamin D deficiency obviously enhances the risk of heart failure in hypertensive patients.