摘要
急性心肌梗死(AMI)是由长期动脉粥样硬化发展而来,其所累及的冠状动脉腔内不稳定性斑块的破裂可导致局部血栓形成、血管堵塞而引发急性心肌缺血的一类心血管系统急症。AMI的首发症状主要为胸痛,患者如得不到及时处治严重者将导致死亡,是一种重要的致死因素。microRNA是一类22nt左右的小RNA,通过结合于靶mRNA3UTR区抑制mRNA转录或降解靶mRNA,从而对疾病的病理生理过程中发挥重要的调节作用。众多研究结果显示,microRNA在AMI的诊断与治疗方面具有巨大潜力。
Acute myocardial infarction （AMI） is caused by long-term development of atherosclerosis. Rupture of transluminal coronary atherosclerosis plaques causes local thrombosis and vascular blockage, resulting in AMI. The main clinical symptom is chest pain and patients who do not have timely treatment will die. As an important lethal factor, AMI causes enormous economic and social burden worldwide. MicroRNAs, - 22nt long, inhibit the transcription of mRNA or degrade the targeted mRNA though binding to the 3＇ UTR of mRNA. These play important roles in many human pathophysiological processes. Recent research results show that microRNAs have great potential in the diagnosis and treatment of AMI.
出处
《心脏杂志》
CAS
2013年第5期592-594,602,共4页
Chinese Heart Journal
