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骨髓间充质干细胞修复心肌损伤的研究进展 被引量：3

Research progress of bone marrow mesenchymal stem cells in the repair of myocardial injury
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摘要 心肌梗死(MI)具有较高的死亡率,大面积MI后幸存的患者,常因心肌结构重构而逐渐发展为心力衰竭,预后往往欠佳。近来研究发现,骨髓间充质干细胞(bone marrow mesenchymal stem cells,BMSCs)作为多潜能干细胞,对受损的心肌具有积极的修复作用,为改善MI患者的预后提供了一个新途径。本文主要就BMSCs修复受损心肌的相关机制作一综述。 Myocardial infarction （MI） has a high mortality. Survival of MI in patients usually gradually develops into heart failure due to myocardial remodeling. The prognosis is poor. Recent studies have shown that bone marrow tive effect on the damag mesenchymal stem cells （BMSCs）, a type of pluripotent stem cells, have a poslive effect on the damaged myocardium, which provides a therapeutic alternative for improving the prognosis of MI patients. This article mainly reviews the mechanism of BMSCs in cardiac repair.
作者 沈利水 屈百鸣
机构地区 浙江中医药大学第二临床医学院 浙江省人民医院心内科
出处 《心脏杂志》 CAS 2013年第5期620-622,共3页 Chinese Heart Journal
关键词 骨髓间充质干细胞 心肌梗死 损伤 修复 bone marrow mesenchymal stem cells myocardial infarction injury repair
分类号 R542.2 [医药卫生—心血管疾病]
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参考文献12

  • 1Caplan AI.Why are MSCs therapeutic? New data: new insight[J].J Pathol,2009,217(2):318-324.
  • 2Ren G,Zhang L,Zhao X,et al.Mesenchymal stem cellmediated immunosuppression occurs via concerted action of chemokines and nitric oxide[J].Cell Stem Cell,2008,2(2):141-150.
  • 3Cheng Z,Liu X.Mobilization of mesenchymal stem cells by granulocyte colonystimulating factor in rats with acute myocardial infarction[J].Cardiovasc Drugs Ther,2008,22(5):363-371.
  • 4杨庆有,冼绍祥,孙慧茹,赵立诚,汪朝晖.黄芪含药血清诱导骨髓间充质干细胞分化为心肌样细胞的实验研究[J].辽宁中医杂志,2008,35(6):832-834. 被引量：23
  • 5Quevedo HC,Hatzistergos KE,Oskouei BN,et al.Allogeneic mesenchymal stem cells restorecardiac function in chronic ischemic cardiomyopathy via trilineage differentiating capacity[J].Proc Natl Acad Sci U S A,2009,106(33):14022-14027.
  • 6Zhang S,Ge J,Sun A,et al.Comparison of various kinds of bone marrow stem cells for the repair of infarcted myocardium: single clonally purified nonhematopoietic mesenchymal stem cells serve as a superior source[J].J Cell Biochem,2006,99(4):1132-1147.
  • 7Dixon JA,Gorman RC,Stroud RE,et al. Mesenchymal cell transplantation and myocardial remodeling after myocardial infarction[J].Circulation,2009,120(11 Suppl):220-229.
  • 8Mirotsou M,Zhang Z,Deb A,et al. Secreted frizzled related protein 2 (Sfrp2) is the key Aktmesenchymal stem cellreleased paracrine factor mediating myocardial survival and repair[J].Proc Natl Acad Sci U S A,2007,104(5):1643-1648.
  • 9Noiseux N,Gnecchi M,Lopez Ilasaca M,et al.Mesenchymal stem cells overexpressing Aktdramatically repair infarcted myocardium and improve cardiac function despite infrequent cellular fusion or differentiation[J].Mol Ther,2006,14(6):840-850.
  • 10Hatzistergos KE,Quevedo H,Oskouei BN,et al.Bone marrow mesenchymal stem cells stimulate cardiac stem cellproliferation and differentiation[J].Circ Res,2010,107(7):913-922.

二级参考文献4

  • 1Perry SV ,et al. Phosphorylation of troponin and the effects of interactions between the components of the complex [ J ]. Biochem, 1974,141 (3) :733 -743.
  • 2Ordahl CP. Myogenic shape - shifters [ J ]. Cell Bio, 1999,147 (4) : 695 - 700.
  • 3Li ZL,Mericskay M ,Agbulut O,et al. Desmin is essential for the tensile strength and intergrity of myofibrils but not for myogenic commitment, differentiation, and fusion of skeletal muscle [ J ]. Cell Biol, 1997,139( 1 ) :129 - 144.
  • 4Carlsson L, Thornell LE. Desmin - related myopathies in mice and man[J]. Acta Physiol Scand,2001,171(3) :341 -348.

共引文献22

同被引文献27

引证文献3

二级引证文献10

心脏杂志
2013年 第5期

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