血管性认知障碍无痴呆患者血清S-100β蛋白水平变化

Changes of serum S-100β protein level of vascular cognitive impairment no dementia patients

目的探讨血管性认知障碍无痴呆(VCIND)患者血清S-100β蛋白水平变化的临床意义。方法采用病例-对照的研究方法,选择VCIND患者60例为病例组,健康体检者30例为对照组。采用酶联免疫吸附法测定2组血清中S-100β蛋白水平。结果病例组患者S-100β蛋白水平为(0.697±0.478)μg·L-1,对照组患者为(0.375±0.248)μg·L-1。病例组患者血清S-100β蛋白水平显著高于对照组患者(t=2.93,P<0.05)。结论血清S-100β蛋白水平的检测对早期发现VCIND患者具有极其重要的意义。

Objective To explore the clinical significance of changes of serum S-100β protein level of vascular cogni- tive impairment no dementia （VCIND） patients. Methods The case-control study was used in this study. Sixty VCIND pa- tients were selected as the case group and thirty health physical examination person were selected as control group. The serum S-100β protein level of all cases were detected by enzyme linked immunosorbent assay. Results The serum S-10β protein level was（0,697 ±0.478） μg . L-1 in case group and （0. 375 ±0. 248）μg . L-1 in control group;the serum S-100β protein level in case group was significantly higher than that in control group （ t = 2.93,P 〈 0.05 ）. Conclusion The detection of ser- um S-100β protein has important significance to the early discovery the VCIND patients.