丙泊酚与七氟醚用于小儿全身麻醉的效应及不良事件发生率的Meta分析

Effect and incidence of side effect of propofol versus sevoflurane for pediatric general anesthesia:a Meta-analysis

目的系统性评价丙泊酚与七氟醚分别用于小儿全身麻醉的药理学效应及不良事件的发生率。方法计算机检索PubMed、Web of Science、Coharane图书馆、万方数据库、CNKI、VIP等数据库检索相关文献,并对相关文献的参考文献进行进一步的检索。收集所有相关的随机对照试验,采用Jadad方法评价纳入文献的质量,用Rev Man5.0软件对收集的资料进行Meta分析。结果最终纳入8个随机对照试验共计938例接受全身麻醉诱导的患者。Meta分析的结果显示:2组间喉罩或气管插管成功置入时间及拔管时间差异无统计学意义(P>0.05);丙泊酚组术后躁动事件发生率显著低于七氟醚组(P<0.05);丙泊酚组在小儿全身麻醉不良事件发生率显著低于七氟醚组(P<0.05)。结论小儿全身麻醉中,丙泊酚与七氟醚在喉罩或气管插管置入时间及拔管时间无差别,但七氟醚麻醉后术后躁动及不良反应发生概率多于丙泊酚。

Objective To systematic review the effect and incidence of side effect of propofol or sevoflurane for pediat- ric general anesthesia. Methods The PubMed, Web of Science, Cochrane Library, Wanfang Database, CNKI and VIP were searched to obtain studies concerning the effect of sevoflurane versus propofol for pediatric anesthetic induction. The quality of studies was evaluated by the Jadad. Meta-analysis was conducted using the Cohrane Collaboration＇s RevMan 5.0 software. Re- stilts Eight randomized-controlled trials（RCTs） involving 938 patients who accepted general anaesthesia induction were in- cluded. Times of laryngeal mask or trachel insertion and extubation were similar in the both groups （ P 〉 0.05 ）. There was a less frequent rate of postoperative agitation in the propofol group compared with the sevoflurane group（ P 〈 0.05 ）. Incidence of side effect in propofol group was significantly lower than that in the sevoflurane group （ P 〈 0.05 ）. Conclusion Times of la- ryngeal mask or traehel insertion and extubation are similar in both groups for the pediatric general anesthesia. But sevoflurane group has a higher frequent of postoperative agitation and side effect compared with propofol group.