摘要
目的优化复方栀子凝胶处方组成,确定复方栀子凝胶的最佳处方工艺。方法采用正交试验方法,通过耐寒耐热实验,对凝胶处方的基质进行优化筛选,以涂展性、光泽性、均匀度、离心稳定性以及体外透皮释放性能为指标,对处方的其他辅料进行优化筛选。结果最佳的凝胶处方组成为卡波普940 1.5%,丙二醇1.5%,甘油3%,三乙醇胺5%,氮酮5%。结论优化后的处方更加可靠、稳定,能够满足复方栀子凝胶的生产要求。
Objective To optimize the prescription of Compound Zhizi Gel （CZG） and to optimize the prescription technology of CZG. Methods Orthogonal test, cold-resistant and heat-resistant tests were used to optimize the prescription technology. Using spreadability, glossiness, evenness, centrifugal stability, and in vitro transdermal diffusion as indexes, other excipients of prescription were optimized. Results The optimal CZG prescription was Carbopo1940-glycerin-propylene glycol-triethanolamine-azone （1.5% ： 1.5% ： 3% ： 5% ： 5%）. Conclusion The optimized prescription is reliable and stable. It could meet the production requirements of CZG.
出处
《中草药》
CAS
CSCD
北大核心
2013年第21期2982-2987,共6页
Chinese Traditional and Herbal Drugs
关键词
复方栀子凝胶
丹皮酚
阿魏酸
栀子苷
氮酮
透皮释放
Compound Zhizi Gel
paeonol
ferulic acid
geniposide
azone
transdermal diffusion
