不同海拔人群肺功能检测分析与研究

Research of Pulmonary Function of Population at Different Geographic Altitudes

目的：比较不同海拔高度下健康人群肺功能指标的变化，为低氧环境对人体肺功能损伤的机理与发病规律提供理论依据。方法：分别选择平原对照组（西安，海拔356m）建筑工人93名、中海拔组（西宁，海拔2260m）’76名、高海拔组（拉萨，3650m）65名、特高海拔组（唐古拉山，海拔5072m）55名，测定其肺功能指标，观察不同海拔高度下肺功能的变化情况。结果：高海拔组与特高海拔组MVV、VC较平原对照组明显下降，差异有统计学意义（P〈0．05），特高海拔组的FVC、FEVl、FEVl／FVC、FEVl／VC值较平原对照组明显下降（P〈0．05），而FEF25％～FEF75％、Vmax25％、Vmax75％VT、ERV、PEF等指标则明显高于平原对照组（P〈0．05），MV值高于平原对照组（P〈0．05），ERV低于平原对照组（P〈0．05）。高海拔组、特高海拔组的ERV、MV、FVC、FEVl、FEVl／FVC、MVV、PEF、Sa02值较中海拔组明显升高（P〈0．05）。血氧饱和度（Sa02）随海拔升高呈逐渐下降趋势。结论：高海拔低氧环境下人的肺通气指标多数低于平原对照组，肺功能明显下降。

Objection：To research the changes of pulmonary function in healthy people at different geographic alti tudes to provide theoretical basis for the echanism and pathogenesis regularity of pulmonary function damages under hy poxic environments. Meflads：The resemeh was consisted of the control group with 93 workers from Xian （356m）, mod erate altitude group with 76 workers in Xining （2 260m）, high altitude group with 65 workers from Iasa （3 650m） and extreme high altitude group with 55 workers from Tanggula mountain （5 072m）. Pulmonary function of all subjects was detected. Results：The levels of MVV and VC in high altitude group and extreme high altitude group were significantly decreased compared with control group （P〈0.05）. The values of FVC ,FEV1, FEV1/FVC and FEV1/VC were obvi ously lower in extreme high altitude group than those in control gToup （P 〈 0. 05）, on the contrary, the levels of FEF25% -75% ,Vmax25% ,Vmax75%T,ERV, PEF were higher than those of control group （P 〈0.05）. The value of MV and ERV was higher and lower respectively than control group （P 〈 0.05）. Cousions： The pulmonary ventilation and function was lower and decreased siificanflv under high altitude environment than in lowland.