多西他赛致迟发性腹泻和肺水肿

Pulmonary edema and delayed-onset diarrhea caused by docetaxel

1例52岁女性乳腺癌患者术后化疗方案为表柔比星+环磷酰胺4个周期,序贯多西他赛4个周期。患者在多西他赛治疗每个周期的第10天左右均出现水样便,给予蒙脱石散口服后腹泻消失。多西他赛序贯化疗前患者胸部CT未见异常改变,多西他赛化疗结束后胸部CT示双肺渗出。2个月后双肺渗出消失。

A 52-years-old female patient with breast cancer received chemotherapy regimen（epirubicin and cyclophosphamide for 4 cycles followed by docetaxel for another 4 cycles） after operation. She experienced diarrhea with watery stool around 10 days after each treatment cycle of docetaxel,was treated with montmorillonite powder and her diarrhea disappeared.A chest CT scan revealed no abnormal finding before sequential chemotherapy with docetaxel,while effusion in both lungs after docetaxel chemotherapy.Two months later,effusion in both lungs disappeared.