血清促甲状腺素水平对高尿酸血症患病率的影响

Effects of Serum Thyroid Stimulating Hormone Level on Prevalence of Hyperuricemia

目的:探讨血清促甲状腺素(TSH)水平对高尿酸血症患病率的影响。方法:回顾性分析20岁以上健康体检者2252例的临床资料。结果:(1)高尿酸血症的患病率为14.2%,其中男性19.3%,女性9.6%。(2)甲状腺功能异常患病率为9.0%,男性3.1%,其中TSH降低者0.7%,TSH升高者2.5%;女性14.2%,其中TSH降低者4.2%,TSH升高者10.0%。(3)与TSH正常组相比,不论性别,TSH升高组的血尿酸水平均显著升高(P<0.05),TSH降低组的血尿酸水平无显著变化。(4)TSH升高是高尿酸血症的独立影响因素(OR值男性为1.75,女性为1.83,P均<0.01)。结论:高尿酸血症患病率与血清TSH升高显著相关,临床或亚临床甲状腺功能减退症可能是高尿酸血症的危险因素。

Objective： To study the effects of serum TSH level on the prevalence of hyperuricemia. Methods： The clinical data of 2252 cases from medical examination among adults age ≥ 20 years were analyzed retrospectively. Results： （1）The prevalence of hyperuricemia was 14.2% of the population, 19.3% in male and 9.6% in female.（2） The prevalence of thyroid dysfunction was 9.0%,3.1% in male and 14.2% in female. The percentage of subjects with low TSH concentration was 0.7% in male and 4.2% in female, the percentage of subjects with elevated TSH concentration was 2.5% in male and 10.0% in female. （3）Compared with normal TSH subjects,the serum uric acid was significantly increased in subjects with high TSH （P〈0.05） and not changed in subjects with low TSH in both genders. （4）Logistic regression analysis revealed that high TSH was an independent factor associated with hyperuricemia （OR=1.75 for male and 1.83 for female, P〈0.01）. Conclusion： The prevalence of hyperuricemia is significantly associated with increased TSH concentration. Overt or subclinical hypothyroidism may be risk factors for hyperuricemia.