546株常见病原菌耐药分析

Analysis of Drug Resistance of 546 Common Clinical Pathogens

目的对546株常见病原菌进行耐药分析,为感染性疾病的临床治疗提供依据。方法对2012年4月-9月从临床标本中分离的546株常见病原菌进行耐药分析,菌种鉴定及药物敏感试验结果由法国生物梅里埃公司VITEK 2 COMPACT系统完成。结果在546株病原菌中,G杆菌占82.8%,其前3位分别为大肠埃希菌(占22.2%),鲍曼/溶血不动杆菌(占16.5%),肺炎克雷伯菌(占15.4%)。在G杆菌中,除嗜麦芽窄食单孢菌外,亚胺培南、厄它培南的耐药率最低,其次为丁胺卡那霉素和哌拉西林/他唑巴坦。鲍曼/溶血不动杆菌、肺炎克雷伯菌、铜绿假单孢对氨苄青霉素的耐药率均超过95%。金黄色葡萄球菌的耐药率较凝固酶阴性葡萄球菌低,耐甲氧西林金黄色葡萄球菌占22.00%;而耐甲氧西林凝固酶阴性葡萄球菌占94.44%。此外,金黄色葡萄球菌和凝固酶阴性葡萄球菌对万古霉素、利奈唑胺、替加环素、奎奴普丁/达福普丁、呋喃妥因的耐药率为0.00%。结论在该院新院区临床标本分离的常见病原菌中,仍以G杆菌占优势。在G杆菌中,除嗜麦芽窄食单孢菌外,亚胺培南、厄它培南的耐药率最低。金黄色葡萄球菌的耐药率较凝固酶阴性葡萄球菌低,且尚未发现对万古霉素耐药的葡萄球菌。

Objective To investigate the drug resistance of 546 common pathogens to provide the basis for the treatment of the infectious diseases. Methods From April to September 2012, 546 common pathogens isolated from clinical specimens species were analyzed. The identification and susceptibility testing were performed by VITEK 2 compact system （BioM6rieux, France）. Results Among 546 strains of the pathogen, Gram-negative bacteria were predominant （82.8%）. Escherichia coli ranked the first place （22.2%）, followed by Acinetobacter baumanii/haemolylicus （16.5%） and Klebsiella pneumonia （15.4%）. Among Gram-negative bacteria except Strenotrophomonas maltrophilia, the drug resistance of imipenem and ertapenem was the lowest, followed by amikacin and piperacillin/tazobactam. Resistant rate of Ampicillin to Baumanii, Klebsiella pneumoniae and Pseudomonas aeruginosa was more than 95%. The drug resistance of Staphylococcus aureus was lower than that of coagulase negative Staphylococcus. Methicillin resistant Staphylococcus aureus （MRSA） was 22.00%, while Methicillin resistant coagulase negative Staphylococcus （MRCNS） was 94.44%. Furthermore, Staphylococcus aureus and coagulase negative Staphylococcus strains were sensitive to vacomacin, linezolid, tigecycline, quinupristin/dalfopristin and furantoin. Conclusions Among clinical common pathogens, the preponderant strain was Gram-negative bacteria. Among Gram-negative bacteria except Strenotrophomonas maltrophilia, the drug resistance of imipenem and ertapenem is the lowest. The drug resistance of Staphylococcus aureus is lower than that of coagulase negative Staphylococcus. As yet, there was no vancomycin resistant Staphylococcus strains in our new school district hospital.