自身免疫性胰腺炎的研究进展

Current status of research on autoimmune pancreatitis

自身免疫性胰腺炎(autoimmune pancreatitis,AIP)是一种慢性胰腺炎症,以慢性阻塞性黄疸、淋巴浆细胞组织浸润、纤维化以及对类固醇激素治疗应答为特征.AIP分2个亚型,1型为淋巴浆细胞硬化性胰腺炎(lymphoplasmacytic sclerosing pancreatitis,LPSP),2型为特发性导管中心性胰腺炎(idiopathic duct centric pancreatitis,IDCP).AIP的发病机制可能涉及遗传易感性、自身抗体、分子模拟、T细胞免疫调节失衡以及基因突变等.本文系统地阐述了AIP患者的临床、影像及组织病理学的典型及非典型特征.此外,本文还重点阐述了AIP的诊断和治疗进展.

Autoimmune pancreatitis （AIP） is a form of chronic pancreatitis characterized clinically by frequent presentation with obstructive jaundice, histologically by lymphoplasmacytic infiltration with fibrosis, and therapeutically by a dramatic response to steroids. AIP have recently been clas- sified into two subtypes, lymphoplasmacytic sclerosing pancreatitis （LPSP） and idiopathic duct centric pancreatitis （IDCP）. The pathogenesis of AIP may involve genetic susceptibility, autoanti- bodies, molecular mimicry, imbalance of T-cell- mediated immune regulation, and gene mutation. In this article, we will systematically review typi- cal and atypical clinical, imaging and histopatho- logical features of AIP, with an emphasis placed on the advances in the diagnosis and treatment of this disease.