平顶山市矿区非酒精性脂肪肝的患病率及危险因素

Prevalence and risk factors for non-alcoholic fatty liver disease in the mining area of Pingdingshan city

目的:了解平顶山市矿区非酒精性脂肪肝(non-alcoholic fatty liver disease,NAFLD)患病率及其危险因素,为矿区NAFLD防治提供可能科学依据.方法:通过整群抽样的方法,抽取2012-06/2013-04在平顶山市矿区66个区队2299例地面工作人员进行NAFLD患病率调查,采用单因素和多因素Logistic回归分析非酒精性脂肪肝的相关危险因素.结果:(1)2299例工作人员NAFLD的患病率为22.48%(5 1 7/2 2 9 9),其中,男性患病率为31.12%(366/1176),女性患病率为13.41%(151/1123),男女患病率间差异有统计学意义(P<0.05);(2)多因素Logistic回归分析显示,腰围(OR=5.948)、体质量指数(body mass index,BMI)(OR=4.708)、高脂血症(OR=3.781)、高尿酸血症(OR=3.239)、高血糖(OR=2.363)、高血压(OR=1.976)、胆石症(OR=2.722)、肝功异常(OR=2.430)为平顶山矿区地面工作人员非酒精性脂肪肝的主要危险因素(P<0.05).结论:性别(男)、超质量、高脂血症、高尿酸血症、高血糖、高血压、胆石症、肝功异常可能是非酒精性脂肪肝发病的危险因素,应有针对性的进行干预.

AIM： To analyze the prevalence of and main risk factors for non-alcoholic fatty liver disease （NAFLD） in Pingdingshan city. METHODS： A total of 2299 participants were selected from 66 crew teams in Pingdingshan city by cluster random sampling. Question- naires were used to investigate the prevalence of NAFLD, and non-conditional Logistic regressionanalysis was used for analysis of risk factors for NAFLD. RESULTS： The overall prevalence of NAFLD was 22.48% （517/2299）. The prevalence rate of NAFLD was significantly higher in males than in females [31.12% （366/1176） vs 13.41% （151/1123）, P 〈 0.05]. Overweight （OR = 4.708）, hyperlipid- emia （OR = 3.781）, hyperuricemia （OR = 3.239）, high blood sugar （OR = 2.363）, hypertension （OR = 1.976）, cholelith disease （OR = 2.722）, and ab- normal hepatic function （OR = 2.430） were risk factors for NAFLD （all P 〈 0.05）. CONCLUSION： Gender （male）, overweight, hy- perlipidemia, hyperuricemia, high blood sugar, high blood pressure, cholelith disease, and ab- normal hepatic function are related to NAFLD. Targeted interventions are necessary to reduce and prevent the occurrence of NAFLD.