血管内皮生长因子受体在子宫颈癌组织中的表达及其意义

Expression of Vascular Endothelial Growth Factor Receptor Kinase Inser Domain Containing Receptor in Human Cervical Carcinoma

目的 观察血管内皮生长因子 (VEGF)受体 (KDR)在子宫颈癌组织中的表达情况 ,探讨其与子宫颈癌的生长、浸润及转移的关系。方法 用免疫组织化学法检测 80例子宫颈癌组织中KDR的表达情况 ,染色强度 (- )～ (+)者为KDR低表达 ,染色强度 (++)者为KDR高表达。结果 在肿瘤间质血管内皮细胞中KDR的表达为 ,临床分期≤Ⅰb者和Ⅱa～Ⅲa者的高表达率分别为 2 1 4%和6 0 6 % (P <0 0 1) ;病理分化程度为高、中、低分化者的高表达率分别为 7 7%、2 7 8%和 84 1% ,分别比较 ,差异均有极显著性 (P均 <0 0 1) ;5例腺癌中无一例KDR高表达 ,而鳞癌的高表达率为 5 7 3% ,两者比较 ,差异有显著性 (P <0 0 5 ) ;有、无淋巴结转移者的高表达率分别为 77 8%和 46 8% ,两者比较 ,差异有显著性 (P <0 0 5 ) ;KDR高表达者的 3年和 5年生存率分别为 6 9%和 5 1% ,显著低于KDR低表达者的 95 %和 82 % (P <0 0 5 )。结论 KDR在子宫颈癌组织中的表达与肿瘤的生长、浸润及转移密切相关 ,可作为反应子宫颈癌生物学行为的指标之一。

Objective To observe the expression of vascular endothelial growth factor receptor (KDR)in human cervical carcinomas, to clarify the relationship between the expression and invasion, metastasis, prognostic value in human cervical carcinoma. Methods KDR was stained immunohistochemically in 80 cases of human cervical carcinoma. Results The expression of KDR in the endothelial cells of tumor vasculature is: the high KDR expression rate of clinical cancer stages ≤Ⅰb and Ⅱa～Ⅲa was 21 4% and 60 6% (P< 0 01). The high KDR expression rate of the high, middle and low pathohistologic grading was 7 7%、27 8% and 84 1% respectively (P< 0 01). The high KDR expression rate of adenocarcinoma and squamous cell carcinoma was 0/5 and 57 3% (P< 0 05). The high KDR expression rate of the cases with lymphonodus metastasis and without lymphonodus metastasis was 77 8% and 46 8% respectively (P<0 05). The survival rate of patients with high KDR expression tumors was significantly lower than that of patients with low KDR expression (P<0 05). Conclusion KDR is highly related to growth, invasion and metastasis of human cervical carcinoma, it may be one of the predictors for the biological behavior of human cervical carcinoma.