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靶向药物治疗晚期肾癌进展 被引量:7

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摘要 肾癌是较常见的恶性肿瘤,2009年美国癌症统计肾癌占所有新发恶性肿瘤的4.2%,且发病率以每年2.0%的速度递增[1].就诊时25%的患者已有远处转移,局限性肾癌手术切除后1/3病例出现远处转移[2].肾癌对放化疗不敏感,免疫治疗总有效率仅15%.2005年美国FDA首先批准靶向治疗药物索拉非尼用于治疗晚期肾癌,随后相继有多种药物批准上市,为晚期肾癌的治疗揭开了新的序幕.
出处 《现代泌尿生殖肿瘤杂志》 2013年第5期311-314,共4页 Journal of Contemporary Urologic and Reproductive Oncology
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  • 1Adamy A, Chong KT, Chade D, et al. Clinical characteristics and outcomes of patients with recurrence 5 years after ne- phrectomy for localized renal cell carcinoma [J]. J Urol, 2011,18S,(2):433 -438.
  • 2Cohen HT, McGovern FJ. Renal cell carcinomaEJ]. N Engl J Med,2005,353(23) :2477-2490.
  • 3Stadler WM, Figlin RA, McDermott DF, et al. Safety and efficacy results o{ the advanced renal cell carcinoma sorafenib expanded access program in North America [J]. Cancer, 2010,116(5):1272 -1280.
  • 4Motzer RJ, Hutson TE, Tomczak P, et al. Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma[J]. J Clin On- col, 2009,27 (22) : 3584-3590.
  • 5Gore ME, Szczylik C, Porta C, et al. Safety and efficacy o{ sunitinib for metastatic renal-cell carcinoma: an expanded-ac cess trialEJ]. Lancet Oncol, 2009,10(8) : 757-763.
  • 6Rini BI, Wilding G, Hudes G, et al. Phase II study of ax- itinib in sorafenib-refractory metastatic renal cell carcinoma EJ]. J ClinOncol,2009,27(27):4462-4468.
  • 7Hutson TE, Davis ID, Machiels JP, et al. Efficacy and safety of pazopanib in patients with metastatic renal cell carcinoma EJ]. J ClinOncol,2010,28(3):475-480.
  • 8Bellmunt J, Szczylik C, Feingold J, et al. Temsirolimus safe ty prof!lo and management of toxic effects in patients with ad- vanced renal cell carcinoma and poor prognostic features[J]. Ann Oncol, 2008,19(8) 1387-1392.
  • 9Jac J, Giessinger S, Khan M, et al. A phase II trial of RAD001 in patients (Pts) with metastatic renal cell carcinoma (mRCC) EJ3. J Clin Oncol (Meeting Abstracts 5107),2007,25(18S).
  • 10Motzer RJ, Escudier B, Oudard S, et al. Phase 3 trial of everolimus for metastatic renal cell carcinoma : final results and analysis of prognostic factorsEJ]. Cancer, 2010,116(18) 4256 -4265.

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