双氯醇胺对山羊胃肠电活动及运动的影响

Effect on the Gastrointestine Electric Activities and Rumen Movements of Goat with Clenbuterol

采用在瘤胃背囊、皱胃幽门部和十二指肠近端安装有双极胃肠电极及应力传感器的土种公山羊 5头 ,按自身对照设计 ,研究了双氯醇胺对山羊胃肠电活动及运动的影响。结果表明 ,β 激动剂双氯醇胺在功能上有与肾上腺素相似的作用 ,即可直接或间接地抑制山羊胃肠道电活动和运动。与对照期相比 ,给山羊皮下注射双氯醇胺后 ,其瘤胃背囊、皱胃幽门部及十二指肠近端的快、慢波电位振幅显著降低 (p <0 0 5) ,瘤胃运动的应力波值极显著减小 (p <0 0 1) ,但快、慢波频率无明显变化。瘤胃运动的应力波值与瘤胃快波电位振幅以及应力波延续时间与快波峰电位数间呈强正相关 (R值分别为 0 94± 0 32和 0 85± 0 2 7)。体外试验结果亦显示 ,双氯醇胺可使离体十二指肠段的快、慢波电位振幅减小 ,张力波值大幅度下降 。

In this experiment five native male goats fitted with gastrointestine electrodes and a strain gauge were used to study the effect of clenbuterol on the gastrointestine electric activities and rumen movements. The results showed that compared with the control period, after injecting clenbuterol subcutandously, the amplitude of the fast wave potentials and slow wave potentials at the duodenal close to abomasum, the pylorus of abomasum and dorsal sac of the rumen, as well as the strainwave of rumen movements showed a striking decrease, respectively (p<0.01), but there was no noticeable change in their frequencies. Clenbuterol also greatly inhibited the electric activities and movements of the duodenal in vitro (p<0.05). The above results showed that clenbuterol had a direct and indirect inhibitory effect on the gastrointestine electric activities and movements of goats.