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全器官组织工程:三维支架的去细胞化和复细胞化

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摘要 器官移植是终末期脏器功能衰竭的最终治疗手段.然而,器官供体严重匮乏,致使每年成千上万的患者在等待中死亡.即使有幸接受器官移植,患者将面对发生慢性移植物排斥的风险以及终身使用免疫抑制剂的危害.虽然组织工程技术取得了显著的进步,可以进行血管[1-2]、膀胱[3]和气管[4-5]的构建,但这些器官相对简单,在移植时无需与宿主的循环系统形成完整的血管网络.而复杂的心脏、肺、肝脏等器官的构建则不相同,这些器官移植时需要即刻的血液供应.因此,寻找成功的再生医学策略进行全器官的构建将是治疗终末期疾病的巨大飞跃.
机构地区 Department of Surgery
出处 《中华细胞与干细胞杂志(电子版)》 2013年第3期40-47,共8页 Chinese Journal of Cell and Stem Cell(Electronic Edition)
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