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血清储存条件和冻融过程对AQP4抗体测定结果的影响 被引量：2

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摘要 视神经脊髓炎（NMO）是一种致残性自身免疫疾病.血清水通道蛋白4（AQP4）抗体有助于对NMO与多发性硬化（MS）进行鉴别,这对临床诊治这两种疾病具有重要意义,因为两者的预后以及疗法不同.血清中的AQP4抗体与NMO发病直接有关[1],且其血清水平与疾病的严重程度相关[2].临床实践中,只有一些检测中心进行该抗体的检查,其他相关单位需要在常温或冰冻的情况下运输标本到检测中心;临床研究中,标本可能多次被检测,可能经过冻融过程.Jarius等[3]于2011年9月在Clin Chem Lab Med杂志发表论文首次报道储存条件和冻融过程对血清AQP4抗体水平的影响.
作者 李海峰 郝洪军 谢琰臣
机构地区 青岛大学医学院附属医院神经内科 北京大学第一医院神经内科 首都医科大学友谊医院神经内科
出处 《中国神经免疫学和神经病学杂志》 CAS 北大核心 2013年第3期227-228,共2页 Chinese Journal of Neuroimmunology and Neurology
关键词 视神经脊髓炎 水通道蛋白4
分类号 R744.52 [医药卫生—神经病学与精神病学]
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参考文献9

  • 1Jarius S,Wildemann B.AQP4 antibodies in neuromyelitis optica:diagnostic and pathogenetic relevance[J].Nat Rev Neurol 2010,6:383-392.
  • 2Jarius S,Aboul-Enein F,Waters P,et al.Antibody to aquaporin-4 in the long-term course of neuromyelitis optica[J].Brain,2008,131:3072-3080.
  • 3Jarius S,Wildemann B.Effect of storage conditions and freeze/thaw cycles on aquaporin-4 antibody (NMO-IgG) serum levels[J].Clin Chem Lab Med,2011,49:2121-2122.
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同被引文献20

  • 1LENNON V A, WINGERCHUK D M, KRYZER T J, et al. A se- rum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis[J]. Lancet, 2004, 364(9451 ): 2106-2112.
  • 2JARIUS S, WILDEMANN B. Aquaporin -4 antibodies (NMO - IgG) as a serological marker of neuromyelitis optica: a critical re- view of the literature[J]. Brain Pathol, 2013, 23(6) : 661 -683.
  • 3JIAO Y, FRYER J P, LENNON V A, et al. Aquaporin 4 lgG serostatus and outcome in recurrent longitudinally extensive trans- verse myelitis[ J ]. JAMA Neurol, 2014, 71 ( 1 ) : 48 - 54.
  • 4LONG Y, GAO C, QIU W, et al. Antibodies target microvessels in neuromyelitis optica and multiple sclerosis patients [ J ]. Neurol Res, 2013, 35(9) : 922 -929.
  • 5LONG Y, QIU W, LU Z, et al. Aquaporin 4 antibodies in the ce- rebrospinal fluid are helpful in diagnosing Chinese patients with neuromyelitis optiea [ J ]. Neuroimmunomodulation, 2012, 19(2) : 96 - 102.
  • 6KLAWITER E C, ALVAREZ E 3RD, XU J, et al. NMO - IgG detected in CSF in seronegative neuromyelitis optica[ J ]. Neurolo- gy, 2009, 72(12) : 1101 - 1103.
  • 7MILLER D H, WEINSHENKER B G, FILIPPI M, et al. Diffe-rential diagnosis of suspected multiple sclerosis: a consensus ap- proach[J]. Mult Scler, 2008, 14(9) : 1157 - 1174.
  • 8RATELADE J, BENNETT J L, VERKMAN A S. Intravenous neuromyelitis optica autoantibody in mice targets aquaporin -4 in peripheral organs and area postrema [ J ]. PLOS One, 2011, 6 (11) : e27412.
  • 9LENNON VA, WINGERCHUK DM, KRYZER TJ, et al. A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis [J]. Lancet, 2004, 364(9451): 2106- 2112.
  • 10JARIUS S, WILDEMANN B. Effect of storage conditions and freeze/thaw cycles on aquaporin-4 antibody (NMO-IgG) serum levels [J]. Clin Chem Lab Med, 2011, 49(12) : 2121-2122.

引证文献2

中国神经免疫学和神经病学杂志
2013年 第3期

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