东川雪上一支蒿的化学成分研究

Chemical constituents of Aconitum brachypodum from Dong-Chuan area

雪上一支蒿是著名的有毒中药,但其化学成分研究报道较少,为进一步阐明其化学成分,作者开展了其80%乙醇提取物的化学成分研究,利用各种色谱方法从其块根中分离得到17个化合物,经过波谱学鉴定为:次乌头碱(1)、中乌头碱(2)、塔拉地萨敏(3)、尼奥灵(4)、附子灵(5)、乌头胺(6)、雪上一支蒿甲素(7)、雷乌宁(8)、宋果灵(9)、异可利定(10)、β-谷甾醇(11)、胡萝卜苷(12)、硬脂酸(13)、三十烷醇(14)、软脂酸(15)、苯甲酸(16)、肌苷(17)。除化合物1,7外,其余15个化合物为首次从该植物中分离得到。

Aconitum brachypodum is traditionally known to be toxic chinese medicie, but its chemical constituents is not enough studied to date. To further elucidate the chemical constituents of A. brachypodum, 80% ethanol extract of A. brachypodum collected from Dong-Chuan area was investigated, which led to isolation of seventeen compounds. By spectroscopic methods, their structures were determined as hypaconitine （ 1 ）, mesaconitine （2）, talatisamine （ 3 ）, neoline （ 4 ）, fuzihne （ 5 ）, aconine （ 6 ）, bullatine A （7）, lepeine（8）, songrine（9）, isocorydine（10）, β-sitosterol（11）, daucosterol（12）, stearic acid（13）, triacontanol（14）, palmitic acid（15）, benzoic acid （16）, and inosine （17）, respectively. All compounds except for compounds 1 and 7 were isolated from A. brachypodum for the first time.