联用黛力新治疗功能性消化不良临床分析

Clinical analysis of deanxit combination in the treatment for patients with functional dyspepsia

目的:探讨奥美拉唑、依托必利联合黛力新治疗功能性消化不良(FD)临床疗效。方法:将我院消化内科门诊或住院的232例功能性消化不良患者,依据治疗方式不同随机分为对照组115例,口服伊托必利片,50mg,每日3次,奥美拉唑,20mg,每12小时1次;治疗组117例,在对照组基础上加用黛力新,10.5mg,早晨、中午各1次;两组疗程均为4周;观察两组患者临床症状、焦虑及抑郁症状改善情况及临床疗效,并进行对比分析。结果:治疗组临床治疗总有效率较对照组差异有统计学意义(总有效率:治疗组:92.30%,对照组:56.52%,χ2=232.00,P<0.01);治疗前治疗组抑郁症状及焦虑症状较对照组差异无统计学意义(SDS:t=0.75,P>0.05,SAS:t=0.54,P>0.05),治疗后治疗组抑郁症状及焦虑症状改善均较对照组差异有统计学意义(SDS:t=20.12,P<0.01;SAS:t=15.65,P<0.01)。结论:奥美拉唑、依托必利联合黛力新治疗功能性消化不良临床治疗效果明显,特别对于改善患者的焦虑及抑郁症状明显优于奥美拉唑联用依托必利,是目前治疗FD较为有效的方案,值得临床推广应用。

Objective： To investigate the efficacy of omeprazole and itopride combined with deanxit in the treatment for patients with functional dyspepsia （FD）. Methods： 232 patients with functional dyspepsia who were visited gastroenterology clinic or were admitted in the hospital were randomly divided into control group and treatment group according to different treatment modalities. There were 115 cases in control group who were given itopride tablets,50mg,tid,oraUy and omeprazole,20mg,ql2h. AdditionaUy,117 cases in treatment group were administrated with deanxit, 10.5mg, bid（morning and noon）. The course of treatment lasted four weeks in which clinical symptoms, the conditions of anxiety and depression,the clinical efficacy of all the patients were observed and comparatively analysed.Results： There was a significant difference of total effective rate between two groups（the total effective rate of the treatment group was 92.30% while 56.52% in the control group,x2=232,00,P〈O.O1 ）. Before treatment, the difference of depressive symptoms and anxiety symptoms of patients between two groups were not statistically significant （SDS：t=0.75,P〉0.05;SAS： t=0.54,P〉0.05）. But after fourweek treatment, the improvement of depressive symptoms and anxiety symptoms were more significant in the treatment group than that in the control group （SDS：t=20.12,P〈0.01 ;SAS：t=15.65 ,P〈0.01 ）. Conclusion： The clinical effect of omeprazole, itopride combined with deanxit in the treatment for patients with functional dyspepsia is obvious. And deanxit combination is more benefit for the improvement of anxiety and depression, which is worth widely appling to treating FD.