正交试验设计法优选复方沙棘油凝胶剂基质的配方

Optimization of matrix formulation of compound sea buckthorn oil gel by orthogonal design

目的:探讨以卡波姆为主要原料复方沙棘油凝胶剂基质的配方。方法:采用正交实验法,以卡波姆-940,甘油、丙二醇配比和pH值为因素,每因素三水平,以凝胶在60℃水浴中的颜色变化时间及外观性状的综合评价为指标,用L9(34)正交表进行实验,优选出复方沙棘油凝胶剂基质配方。结果:复方沙棘油凝胶剂基质最优配方为卡波姆-940 0.9%,甘油:丙二醇为4%:4%,pH值为6.5。结论:此基质具有凝胶剂的特性,洁白、细腻富有光泽、极易涂布和洗除,无刺激且稳定,可作为复方沙棘油凝胶剂的良好基质。

Objective： To optimize the matrix formulation of compound sea buckthorn oil gel.Methods：The orthogonal design was used to investigate the effect of the ratio of carbomer-940, glycerinum and propylene glycol, the pH of gel. It can be a comprehensive evaluation indicators that the time of color change in the 60℃ water and external properties of the gel to optimize the matrix formulation of compound sea buckthorn oil gel by L9 （3＊） orthogonal array.Results：The optimal formulation of compound sea buckthorn oil gel was 0.9% carbomer-940,4% glycerinum： 4% propylene glycol,the pH 6.5.Conclusion： The matrix has the gels characteristics of white, delicate, rich luster coated and easily rinsed, which can be used as good matrix compound sea buckthorn oil gel.