3009例住院儿童EB病毒感染及相关重症疾病调查

The investigate of infection and related critical illness on 3009 hospitalized children with EB virus

目的：了解庆阳市儿童EB病毒（Epstein-Barr virus,EBV）的感染率、流行情况和相关重症疾病的发生率.方法：对2011年1月1日至2011年12月31日在庆阳市人民医院儿科住院的患儿3009例,采用病毒核酸扩增（PCR）荧光定量检测方法检测全血EBV-DNA载量,分别从性别、年龄及季节、相关重症疾病的发生率等相关因素进行统计分析.结果：3009例住院患儿EBV总体感染率为37.19％,其中3～7岁组最高（57.36％）,EBV感染率随年龄增长而逐渐增高,提示感染率在各年龄组间差异有统计学意义.7～9月（15.31％、15.19％、15.36％）感染率较高,差异有统计学意义（P＜0.05）,提示感染率存在季节性.各年龄组EBV感染率无性别差异.EBV感染后相关重症疾病的发生率达0.53％.结论：庆阳市儿童住院患儿EBV的感染率较国内的既往报道明显降低,但EBV感染后相关重症疾病的发生率较资料报道偏高,3～7岁为感染的高峰年龄段,7～9月感染率较高,EBV的感染无性别差异.

Objective： To understand the children of qingyang city EBV infection rate, prevalence and incidence of severe disease. Methods： From Jan to Dec 2011 in qingyang city people＇s hospital,EBV DNA loads of 3009 cases in pediatric hospitalized children were detected by virus nucleic acid amplification （PCR） fluorescence quantitation in which gender, age, season, and the incidence of severe disease related factors were analyzed.Results： Of 3009 cases,overall infection rate of hospitalized children with EBV was 37.19% among which the highest age was 3-7 years old （57.36%）,and EBV infection rate increased gradually along with the age growth,which shows statistically significant difference between the infection rate in each age group;7-9 month infection rate was higher in which the difference was statistically significant （P〈0.05）;no gender difference was found between EBV infection rates among all age groups;incidence after EBV infection associated with severe disease was 0.53%. Conclusion： Of hospitalized children with EB virus in qingyang city, EBV infection of hospitalized children is significantly lower than the domestic ever reported, and the incidence of severe disease associated with after EBV infection is high compared with data reported in which 3-7 years old are to peak age,7-9（15.31%,15.19%,15.36%） months are higher infection rates, and infection of EBV has no gender differences.