放化疗性口腔黏膜炎发生情况及危险因素的研究进展

Oral Mucositis Incidence and Risk Factors in Cancer Patients with Radiotherapy or Chemotherapy

放化疗导致的口腔黏膜炎的发生率高、危害大,并严重影响患者的治疗、身心健康及生活质量。癌症放化疗性口腔黏膜炎会造成许多负面的和潜在的威胁生命安全的后遗症,尤其是头颈部肿瘤,目前尚无明确的药物预防策略建议。了解口腔黏膜炎的发生、发展情况及危险因素有利于医护人员采取有针对性的防护措施,以提高癌症患者的生活质量,减轻患者的经济负担。

Oral mucositis of chemoradiation with high incidence and serious hazardous, affects the cancer patient＇s quality of life, disease treatment, physical and psychological health. Chemoradiation relat- ed mucositis is associated with many negative and potentially life-threatening sequelae. Patients receiving chemoradiotherapy for head and neck cancers are at high risk for severe oral mucositis,however there are no definitive recommendations on pharmacologic preventive strategies. Medical staff＇s understanding of the emergence, progress and risk factors of oral mucositis is good for taking protective measures, improving the quality of life, and reducing the economic burden of the patients.