Chemerin、内脂素在妊娠期糖尿病中的表达及意义

The Expression and Significance of Chemerin and Visfatin of Gestational Diabetes

目的探讨脂肪因子chemerin、内脂素与妊娠期糖尿病的关系。方法采用酶联免疫吸附实验法检测70例妊娠期糖尿病患者（研究组）以及30例正常妊娠孕妇（对照组）孕24～36周外周血中chemerin、内脂素表达水平。结果随孕周增加，血清内chemerin、内脂素呈逐渐增加趋势，相同时间段内研究组血清chemerin、内脂素的表达均显著高于对照组（x2chcmerin=5．09，P〈0．05；X2=5．00，P〈0．05）且两者呈正相关。结论Chemefin、内脂素可能通过影响糖脂代谢，参与胰岛素抵抗，在妊娠期糖尿病发病中可能有重要作用。

Objective To study the relationship between visfatin and chemerin and gestational diabetes mellitus. Methods The serum expressions level of chemerin and visfatin of pregnant women whose gestation weeks raged from 24 weeks to 36 weeks （including 70 cases of gestational diabetes mellitus patients as study group, and 30 cases of normal pregnant women as control group） were detected with Enzyme-linked immunosorbent assay. Results The serum expressions level of chemerin and visfatin gradually increased with the gestation weeks, and they are significantly higher in the study group; and it had a positive correlation between the two groups （x2 chemenn ~=5.09, P 〈0.05; x2 vitform = 5.00, P 〈0.05）. Conclusions Chemerin and visfatin may involve in insulin resistance by affecting glucose and lipid metabolism, which play important roles in the development of gestational diabetes mellitus.