多西环素和博来霉素治疗恶性胸腔积液的疗效和不良反应分析

Curative Effect and Adverse Reaction Analysis of Doxycycline and Bleomycin for the Treatment of Malignant Pleural Effusion

目的比较观察多西环素和博来霉素治疗恶性胸腔积液的疗效和毒副反应。方法将28例晚期肺癌合并恶性胸积液患者随机分为试验组和对照组各14例，均在给予“GP（吉西他滨＋顺铂）”方案化疗后行胸膜粘连术。试验组予以多西环素0．5g治疗，对照组予以博来霉素1mg／kg（45—60mg）治疗。每例患者至少完成1周期化疗后1周后评价疗效。结果试验组完全缓解4例，部分缓解7例，无效3例。对照组完全缓解3例，部分缓解7例，无效4例。2组，临床疗效比较差异无统计学意义（P〉0．05）。试验组不良反应发生率低于对照组，差异有统计学意义（P〈0．05）。结论多西环素与博来霉素治疗肺癌并恶性胸腔积液的疗效相当．但多西环素治疗的副反应相对较少。

Objective To analyze the curative effect and adverse reaction of Doxycycline and Bleomycin for the treatment of malignant pleural effusion. Methods Twenty-eight cases of advanced lung cancer with malignant pleural effusion patients were randomly divided into experimental group and control group, each with 14 cases. All patients received pleurodesis after given ＂GP （gemcitabine plus cisplatin）＂ chemotherapy. Experimental group was given Doxycycline treatment （0.5 g）, and the control group was given Bleomycin treatment （1 mg/kg, 45 - 60 rag）. Each patient was given at least one course of chemotherapy, and then efficacy was assayed after one week. Results Experimental group had 4 cases of complete remission, 7 cases of partial remission, and 3 cases of ineffectiveness. Control group had 3 cases of complete remission, 7 cases of partial remission, and 4 cases of ineffectiveness. The differences in clinical efficacy of experimental group and control group had no statistically significance （P〉0.05）. The adverse reactions was fewer in the experimental group than in the control group, and the difference was statistically significant （P 〈0.05）. Conclusions Doxycycline and Bleomycin for the treatment of malignant pleural effusion has no significant difference in efficacy, but Doxycycline had fewer side effects.