乙型病毒性肝炎合并发热性感染的临床分析

Clinical Analysis of Hepatitis B Virus Infection with Fever

目的分析乙型病毒性肝炎合并发热性感染。方法调查对象为2011年6月至2012年7月入我院就诊并被确诊为乙肝的患者共34例,随机将所有患者分为对照组(发热组)和治疗组(非发热组),对照组20例,治疗组14例。两组患者治疗时间均为1个月,且全部采用综合保肝的方法予以治疗,主要药物包括:抗生素、苦参素、维生素以及辅酶A等,此外治疗前后还应加强营养支持并合理安排作息时间,比较治疗前后所有患者肝功能的相关检测指标。结果 Chil-Pugh分级统计学意义较为明显,发热的临床患者肝功能受损较大,P<0.01。治疗组治疗后门冬氨酸氨基转移酶与丙氨酸基转移酶明显低于对照组,P<0.01。结论乙肝病毒性肝炎合并发热性感染可引起肝功能的恶化,因此应对病情给予密切关注,并积极给予相关治疗,改善预后,提高治愈率。

Objective To analyze the hepatitis B virus combine with fever. Methods Thirty-four hepatitis B virus infection patients in our hospital from June 2011 to July 2012 were selected and divided into two groups： the control group （fever group） with 20 cases, and the treatment group （non heating group） with 14 cases. Two groups were treated for 1 months, and all with comprehensive hepatoprotective therapy, mainly including： antibiotic drugs, oxymatrine, vitamin and coenzyme A. Nutrition support was strengthened and reasonable arrangements for work and rest time were set before and after treatment. Relevant indicators of liver function were detected before and after treatment in two groups. Results The Chil-Pugh grade showed statistical significance, as impaired liver function was more obvious in fever patients （P 〈0.01）. After treatment, aspartate aminotransferase （AST） and Alanine aminotransferase （ALT） were significantly lower in the treatment group than in control group （P 〈0.01）. Conclusions Hepatitis B viral infection combine with fever can cause deterioration of liver fimction. Therefore, attention should be paid to the illness, and related treatment should be provided actively, so as to improve prognosis and increase the cure rate.