埃索美拉唑治疗胃食管反流性咳嗽的临床研究

Clinical Study on Esomeprazole in the Treatment of Gastroesophageal Reflux Cough

目的探讨埃索美拉唑治疗胃食管反流性咳嗽的临床效果。方法选择在我院接受治疗的胃食管反流性咳嗽患者86例,分为观察组和对照组,观察组采用埃索美拉唑治疗,对照组采用奥美拉唑治疗,观察并比较两组的临床疗效。结果治疗4周后,观察组临床症状改善的总有效率为81.4%,明显高于对照组的总有效率(60.5%);观察组胃镜检查见原病变部位明显好转的总有效率为88.4%,明显高于对照组的总有效率(69.8%)。两组比较,差异均分别有统计学意义(P<0.05)。结论埃索美拉唑治疗胃食管反流性咳嗽,能明显改善患者的临床症状,且疗效好、安全性高。

Objective To analyze and study clinical effect of esomeprazole in the treatment of gastroesophageal reflux cough. Methods Eighty-six cases of gastroesophageal reflux cough patients who were treated at our hospital were chosen and divided into observation group and control group. Esomeprazole was adopted in the observation group, while omeprazole was adopted in the control group for treatment. Two groups＇ clinical curative effects were compared and observed after a period of treatment. Results Observation group＇s overall effective rate of clinical symptom improvement was 81.4%, obviously higher than 60.5% of the control group. Observation group＇s overall effective rate of stomachoscopy was 88.4%, significantly higher than 69.8%of the control group. Conclusions Esomeprazole has significant effect on gastroesophageal reflux cough, and it is worthy of clinical promotion.