肝脏剪切波速与肝纤维化分期及血清肝纤维化指标之间的相关性

Correlation among shear wave velocity of liver,the stage of liver fibrosis and the markers of serum fibrosis

目的:探讨慢性乙型肝炎患者肝脏剪切波速与肝纤维化分期及血清肝纤维化指标之间的相关性。方法:使用ACUSON S2000彩色多谱勒超声诊断仪,测量96例慢性乙型肝炎患者的肝脏剪切波速,分析肝脏剪切波速与肝纤维化分期及血清肝纤维化指标之间的相关性。结果:肝脏剪切波速与肝纤维化分期有显著相关性,相关系数为0.684;肝脏剪切波速与Ⅲ型前胶原、Ⅳ型胶原、层黏蛋白、透明质酸均有显著相关性,相关系数分别为0.398、0.392、0.426和0.376。结论:肝脏剪切波速与肝纤维化分期及血清肝纤维化指标有较好的相关性,可以利用肝脏剪切波速来评估肝纤维化程度。

Objective To investigate the correlation among shear wave velocity of liver, the stage d liver fibrosis and the markers oi set- tun fibrosis. Methods Measured the liver shear wave velocity of 96 patients with chronic hepatisis B by using a ultrasonic instrument named ACUSON $2000. The correlation among shear wave velocity of liver,the stage of liver fibrosis and the markers of serum fibrosis was ana- lyzed. Results shear wave velocity of liver was closely related to the stage of fibrosis classified by liver pathology; shear wave velocity of liv- er was also closely related to procollagen type Ill ,collagen type IV laminin and hyaluronie acid. Conclusion There is a good correlation among the shear wave velocity and the stage of liver fibrosis and the markers of serum fibrosis,and shear wave velocity of liver can be used to assess the degree of liver fibrosis.