摘要
对以β-环糊精(β-CD)与氯乙酸为原料合成羧甲基-β-环糊精(CM-β-CD)的工艺进行了改进。优化工艺条件是:氯乙酸与β-CD的物质的量比为7.2∶1,氢氧化钠与氯乙酸的物质的量比为3.6∶1,在冰水浴中碱化30min后,继续于50℃下醚化6h。在此条件下,CM-β-CD取代度为6.7,产率为48.6%。产物经过红外光谱、氢核磁谱进行了确证。
According to the existed problems as low substitution degree and low yield, carboxymethyl- β-cyclodextrin （CM-fi-CD） synthesis process was improved by using β-CD and monochloroacetic acid as raw materials. The optimum reaction conditions were as follows： n（monochloroacetic acid） ： n（β- CD） =7.2 ： 1, n（sodium hydroxide） ： n（monochloroacetic acid）= 3.6 ： 1, alkalized in ice-water for 30 min, etherized at 50 ℃ for 6 h. Yield and substitution degree are 48.6% and 6.7 respectively under above conditions. The structure of the product was characterized by IR and ^1H NMR.
出处
《精细石油化工》
CAS
CSCD
北大核心
2013年第6期55-58,共4页
Speciality Petrochemicals
关键词
羧甲基-β-环糊精
工艺改进
取代度
产率
carboxymethyl-β-cyclodextrin
process improvement
degree of substitution
yield
