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疏水性肺表面活性蛋白SP-B结构类似物的研究进展 被引量：3

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摘要 肺表面活性蛋白B(SP-B)类似物α作为肺表面活性物质治疗剂,基于天然SP-B蛋白N-端、C-端、连接区域序列为模板的类似物在体外、体内试验中都表现出了良好的活性,其中类似物SP-B1-25与KL4表现最为突出,KL4已成功上市。同时基于SP-B蛋白N-端与C-端连结序列的Mini-B结构和根据其特殊的α螺旋结构设计的合成肽也显示出了很好的生物活性,显示出了成为SP-B替代物的巨大潜力。这些研究成果为人工合成表面活性物质替代天然表面活性物质治疗剂的应用作出了重要贡献。文中综述了SP-B结构类似物的研究进展。
作者 王鹏 王万能 吕婧 蔡晓娜 张良 邱俊 周继红 刘大维
机构地区 重庆理工大学药学与生物工程学院 解放军第八二医院内分泌中心实验室 第三军医大学大坪医院野战外科研究所烧伤与复合伤国家重点实验室
出处 《华西药学杂志》 CAS CSCD 北大核心 2013年第6期636-639,共4页 West China Journal of Pharmaceutical Sciences
基金 军队十二五重大项目资助(AWS11J5008)
关键词 肺表面活性蛋白B 类似物 Α螺旋 疏水性 研究进展
分类号 R97 [医药卫生—药品]
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参考文献24

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同被引文献29

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华西药学杂志
2013年 第6期

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