布地奈德联合溴化异丙托品及3%氯化钠雾化吸入治疗小儿哮喘急性发作的临床观察

Clinical Observation of Budesonide Combined with Iparatropium Bromide and 3% Sodium Chloride in the Treatment of Acute Attack of Pediatric Asthma with Aerosol Inhalation

目的:观察布地奈德联合溴化异丙托品及3%氯化钠雾化吸入治疗小儿哮喘急性发作的疗效与安全性。方法:将180例哮喘患儿随机均分为两组,入选患儿均给予抗炎、吸氧、吸痰、镇静、维持水电解质平衡、纠正酸碱紊乱、补液等对症治疗。对照组患儿在此基础上给予溴化异丙托品及3%氯化钠雾化吸入治疗,观察组患儿在对照组治疗基础上加用布地奈德治疗。观察两组患儿的症状、体征及肺功能改善情况,并比较两组患儿的临床疗效和不良反应发生情况。结果:观察组的显效率及总有效率显著高于对照组,两组比较差异均有统计学意义(P<0.05)。治疗后,观察组患儿的症状、体征及肺功能改善情况显著优于对照组,两组比较差异有统计学意义(P<0.05)。两组患儿均未见明显不良反应发生。结论:布地奈德联合溴化异丙托品及3%氯化钠雾化吸入治疗小儿哮喘急性发作疗效和安全性较好。

OBJECTIVE： To observe clinical efficacy and security of budesonide combined with iparatropium bromide and 3 % sodium chloride on acute attack of pediatric asthma with aerosol inhalation. METHODS： 180 children with bronchial asthma were randomly divided into 2 groups. All children received anti-inflammatory, oxygen, sputum suction, sedation, water and electrolyte balance, correcting acid-base disorders and rehydration. Control group was given iparatropium bromide and 3 % sodium chloride on the basis of conventional treatment; observation group was given budesonide based on control group. Signs and symptoms, improvement of lung function were observed, and clinical efficacy and adverse drug reactions were compared between 2 groups. RESULTS： The efficiency rate and total effective rate of observation group were significantly higher than those of control group; there was statistical significance （P〈0.05）. Compared with control group, clinical symptoms and signs, the improvement of lung function in observation group were improved significantly; there was statistical significance （P〈0.05）. No ADR was found in 2 groups. CONCLUSIONS： Budesonide combined with iparatropium bromide and 3% sodium chloride is effective for acute attack of pediatric asthma with few adverse dug reactions.