膜联蛋白A2和骨桥蛋白在乳腺癌组织的表达及其与乳腺癌生物学行为的关系

Relationship of annexin A2 and osteopontin expression and biological behaviors of breast cancer

目的 观察膜联蛋白A2（Annexin A2）和骨桥蛋白（Osteopontin,OPN）在乳腺癌组织中的表达,探讨两者与乳腺癌发生发展的关系.方法 应用免疫组织化学技术检测50例乳腺癌组织和癌旁组织中Annexin A2和OPN的表达水平,并分析两者与乳腺癌生物学行为的关系.结果 Annexin A2在乳腺癌组织中呈高表达82.00％,在癌旁组织呈低表达36.00％,两者差异有统计学意义（P＜0.01）,Annexin A2表达水平与乳腺癌组织学分级、TNM分期、淋巴结转移有关（P＜0.01）;OPN在乳腺癌组织中呈高表达74.00％,在癌旁组织呈低表达22.00％,两者差异有统计学意义（P＜0.01）,OPN表达水平与乳腺癌TNM分期、淋巴结转移有关（P＜0.05）.结论 Annexin A2和OPN的高表达可能与乳腺癌的生物学行为有关.

Objective To investigate the expression of Annexin A2 and Osteopontin （OPN） in breast cancer tissues and its relationship with pathogenesis of breast cancer.Methods The expression of Annexin A2 and OPN was examined by using immunohistochemical method in 50 cases of human breast cancer tissues and non-cancerous adjacent breast tissues （5 cm away from the margin of breast cancer）.Results The positive expression rate of Annexin A2 in breast cancer tissues was 82.00％,and that in non-cancerous adjacent breast tissues was 36.00％ （P ＜0.01）.The overexpression of Annexin A2 was related to histologic grade,TNM stage and lymph node metastasis （P ＜ 0.05）.The positive expression rate of OPN in breast cancer tissues was 74.00％,and that in non-cancerous adjacent breast tissues was 22.00％ （P ＜ 0.01）.The expression of OPN was closely related with TNM stage and lymph node metastasis of breast cancer （P ＜ 0.05）.Conclusion The overexpression of Annexin A2 and OPN might be correlated with the biological behaviors of breast cancer.