参苓白术散对慢性肾小球肾炎患者免疫功能的影响

Effect of Shenlingbaizhu powder on immune function in patients with chronic glomerulonephritis

目的 观察参苓白术散对慢性肾小球肾炎患者T淋巴细胞亚群CD3＋、CD4＋、CD4＋/CD8＋,免疫球蛋白IgA、IgG、IgM等免疫指标的影响.方法 将65例慢性肾小球肾炎患者随机分为观察组33例和对照组32例,对照组采用常规治疗,观察组在常规治疗的基础上加用参苓白术散.观察两组患者治疗前后血清CD3＋、CD4＋、CD4 ＋/CD8＋,免疫球蛋白IgA、IgG、IgM变化情况及临床症状缓解情况.结果 观察组治疗后较对照组CD3＋、CD4＋、CD4＋/CD8＋水平及免疫球蛋白IgA、IgG水平有效升高,且观察组疗效优于对照组,差异均有统计学意义（P＜0.05）.结论 参苓白术散可提高慢性肾小球肾炎患者的免疫功能,减轻肾组织损伤,改善临床症状.

Objective To observe the effect of Shenlingbaizhu powder on lymphocyte T subtype CD3 ＋,CD4 ＋,CD4 ＋/CD8 ＋,immunoglobulin IgA,IgG,IgM and immune parameters in patients with chronic glomerular nephritis.Methods Sixty-five patients with chronic glomerular nephritis were randomly divided into observation group （33 cases） and control group （32 cases）,patients in control group were given the routine treatment,and patients in observation group were given Shenlingbaizhu powder on the basis of routine treatment.The serum CD3 ＋,CD4 ＋,CD4 ＋/CD8 ＋,immunoglobulin IgA,IgG,IgM changes and clinical symptoms in both groups before and after treatment were observed.Results Compared with the control group,the levels of CD3＋,CD4＋,CD4＋/CD8＋ （P ＜0.05） and immunoglobulin IgA,IgG increased in observation group （P ＜ 0.05） after treatment,and the clinical curative effect of observation group was better than that of control group.There were statistically significant differences between the two groups （P ＜ 0.05）.Conclusions Shenlingbaizhu powder can improve the immune function in patients with chronic glomerulonephritis,reduce the renal tissue damage,and improve the clinical symptoms.