期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

以乙肝病毒核衣壳为靶标的二氢嘧啶类化合物及其作用机制研究进展 被引量：1

Research on anti-HBV mechanism of HAPs targeting on HBV capsid
原文传递
导出
摘要 核衣壳是乙肝病毒(HBV)的核心结构,在HBV复制感染中起到了重要作用。以核衣壳为靶标的二氢嘧啶类化合物(HAPs)是一类全新结构的高活性HBV抑制剂,有望成为一种新型的乙型肝炎治疗药物。本文就HAPs类化合物的结构特点及其抗乙肝作用机制的研究进展进行综述。 The capsid as a core structure of HBV is key to complete the viral life cycle and infection. Het- eroaryldihydropyrimidines（HAPs） targeting on viral capsid was discovered as highly potent and new struc- ture inhibitors of HBV replication in vitro and in vivo, which would be a new kind of anti-HBV drugs. Re- searching on the anti-HBV mechanism of HAPs can benefit to find more effective and safe drugs. In this re- view the progress on the structure of HAPs and the anti-HBV mechanism of HAPs were summarized.
作者 杨秀岩 赵国明 李松
机构地区 沈阳药科大学制药工程学院 军事医学科学院毒物药物研究所
出处 《中国药物化学杂志》 CAS CSCD 2013年第6期493-498,共6页 Chinese Journal of Medicinal Chemistry
基金 国家自然科学基金项目(21172263)
关键词 乙型肝炎病毒 杂环二氢嘧啶类化合物 核衣壳 作用机制 HBV heteroaryldihydropyrimidines （HAPs） capsid mechanism
分类号 R914 [医药卫生—药物化学]
  • 相关文献

参考文献31

  • 1LINK W, KIREHNER J T. Hepatitis B [J]. Am Fam Physician,2004,69( 1 ) :75 -82.
  • 2KIM K H, KIM N D, SEONG B L. Discovery and development of anti-HBV agents and their resistance [J]. Molecules,2010,15 (9) :5878 - 5908.
  • 3DERES K, SCHRODER C H, PAESSENS A, et al. Inhibition of hepatitis B virus replication by drug-in- duced depletion of nucleocapsids [J]. Science, 2003, 299 ( 5608 ) _. 893 - 896.
  • 4MENG D, HJELM R P, HU J, et al. A theoretical model for the dynamic structure of hepatitis B nucleo- capsid[J]. Biophys J,2011, 101 (10) :2476 - 2484.
  • 5SEEGER C, MASOM W S. Hepatitis B virus biology [ J ]. Microbiol Mol Biol Rev,2000,64 ( 1 ) : 51 - 68.
  • 6BELNAP D M, WATFS N R, CONWAY J F. Diver- sity of core antigen epitopes of hepatitis B virus[ J]. Proc Natl Acad Sci USA,2003,100(19) : 10884 - 10889.
  • 7CHEN H, LIU S P, CHEN L, et al. Expression of HBcAg mutant with long internal deletion in Saccha- romyces cerevisiae and obvervation of its self-assem- bly particles by atomic force microscopy (AFM) [J]. Inter J Bio Macrom, 2005,37 ( 5 ) : 239 - 248.
  • 8CHEN H, LU J H, LIANG W Q, et al. Purification of the recombinant hepatitis B virus core antigen( rHB- cAg) produced in the yeast Saccharomyces cerevisiae and comparative observation of its particles by transmission electron microscopy(TEM) and atomic force microscopy (AFM) [ J ]. Micron, 2004,35 ( 5 ) : 311 -318.
  • 9KOSECHEL M, OED D, GEREL SAIKHAN T, et al. Hepatitis B virus core gene mutations which block nucleocapsid envelopment [ J ]. J Virol,2000,74 ( 1 ) : 1-7.
  • 10TAN Z, MAGUIRE M L, LOEB D D, et al. Geneti- cally altering the thermodynamics and kinetics of hepatitis B virus capsid assembly has profound effects on virus replication in cell culture [ J ]. J Virol,2013,87(6) :3208 - 3216.

二级参考文献14

  • 1魏红山,董庆鸣,庄辉,宋淑静,刘志英,成军.乙型肝炎病毒共价闭合环状DNA荧光定量聚合酶链反应法的建立及应用[J].中华肝脏病杂志,2006,14(1):56-58. 被引量：13
  • 2Gripon P, Rumin S, Urban S, et al. Infection of a human hepatoma cell line by hepatitis B virus. Proc Natl Acad Sci U S A, 2002, 99: 15655-15660.
  • 3Deres K, Schroder CH, Paessens A, et al. Inhibition of hepatitis B virus replication by drug-induced depletion of nucleocapsids. Science, 2003, 299: 893-896.
  • 4Stoll-Becker S, Repp R, Glebe D, et al, Transcription of hepatitis B virus in peripheral blood mononuclear cells from persistently infected patients, J Virol, 1997, 71:5399-5407.
  • 5Pante N, Kann M. Nuclear pore complex is able to transport macromolecules with diameters of about 39 nm, Mol Biol Cell, 2002, 13: 425-434.
  • 6Seeger C, Mason WS. Hepatitis B virus biology. Microbiol Mol Biol Rev, 2000, 64: 51-68.
  • 7Ning B, Shih C. Nucleolar localization of human hepatitis B virus capsid protein. J Virol, 2004, 78: 13653-13668.
  • 8Yeh CT, Wong SW, Fung YK, et al. Cell cycle regulation of nuclear localization of hepatitis B virus core protein. Proc Natl Acad Sci U S A, 1993, 90: 6459-6463.
  • 9Yeh CT, Ou JH, Chu CM, et al. Alteration of the subcellular localization of hepatitis B virus core protein by large but not small surface proteins. Biochem Biophys Res Commun, 1994, 203: 1348-1354.
  • 10Kann M, Sodeik B, Vlachou A, et al. Phosphorylation-dependent binding of hepatitis B virus core particles to the nuclear pore complex. J Cell Biol, 1999, 145: 45-55.

共引文献2

同被引文献2

引证文献1

中国药物化学杂志
2013年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部