抗菌肽分子优化设计研究进展

Progresses of antimicrobial peptides molecular optimal design

抗菌肽(AMPs)是生物体内合成的一种具有抗菌活性的多肽类物质,对多种病原体乃至耐药性菌株具有明显的杀伤作用。但由于其易降解,活性不稳定等缺陷受阻于临床应用。随着抗菌肽数据库的发展,并在降低AMPs毒性、提高AMPs抑菌活性、增强AMPs稳定性及生物利用度、克服AMPs体内转运难题的原则指导下,对众多抗菌肽进行分子优化设计,旨在解决目前抗菌肽合成及活性的瓶颈,相信在不久的将来抗菌肽将成为临床上重要抗菌武器。

Antimicrobial peptides （AMPs） which are produced by most living organisms have shown robust activity against a wide variety of pathogens, including drug-resistant bacteria. AMPs have failed to translate these success to the clinic owing to its poor stability and bioavailability. With the development of antimicrobial peptide databases, novel optimal design approaches are applied to deal with problems of production and activity based on the principles of reducing cytotoxicity, improving antimicrobial activity, increasing stability and bioavailability, and overcoming the challenge of delivery. It becomes increasing likely that AMPs will enter the marketplace as valuable antimicrobial weapons in the coming future.